Mammalian Polyamine Metabolism and Function

Overview

Journal IUBMB Life

Specialties Biochemistry
Molecular Biology

Date 2009 Jul 16

PMID 19603518

Citations 339

Authors

Anthony E Pegg

Affiliations

Soon will be listed here.

Abstract

Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.

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