Conformationally Restricted Homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles As Potent Selective Serotonin Reuptake Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2009 Jun 30

PMID 19560923

Citations 3

Authors

Derek J Denhart

Jeffrey A Deskus

Jonathan L Ditta

Qi Gao

H Dalton King

Edward S Kozlowski

Zhaoxing Meng

Melissa A Lapaglia

Gail K Mattson

Thaddeus F Molski

Matthew T Taber

Nicholas J Lodge

Ronald J Mattson

John E Macor

Affiliations

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Abstract

A series of racemic 3-(trans-2-aminomethylcyclopentyl)indoles was synthesized and found to have potent binding to the human serotonin transporter (hSERT). The most active analog was synthesized stereospecifically and the active enantiomer was shown to have high affinity binding to hSERT.

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