Vaccination for Atherosclerosis

Overview

Journal Clin Rev Allergy Immunol

Specialty Allergy & Immunology

Date 2009 Jun 26

PMID 19554480

Citations 5

Authors

Jozelio Freire de Carvalho

Rosa Maria R Pereira

Yehuda Shoenfeld

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is an inflammatory disease, and several antigens have been shown to activate the immune response and affect the development of atherogenesis. This suggests that modulation of the immune system could represent a useful approach to prevent and/or treat this disorder. A vaccination approach might be a useful, effective tool in the modern arsenal of cardiovascular therapy and could possibly be used on a large scale at a low cost. Several modalities of vaccines have been tested against lipoproteins, cholesterol, molecules involved in cholesterol metabolism, atherosclerosis-associated microorganisms, and other molecules (heat shock protein, CD99, vascular endothelial growth factor-receptor, interleukin-2), with promising results. Nevertheless, a deeper understanding of the role of immunization in atherosclerosis will be essential to the use of vaccines in clinical medicine.

Citing Articles

Advances in Glycolysis Metabolism of Atherosclerosis.

Xu R, Yuan W, Wang Z J Cardiovasc Transl Res. 2022; 16(2):476-490.

PMID: 36068370 DOI: 10.1007/s12265-022-10311-3.

Systemic Autoimmune, Rheumatic Diseases and Coinciding Psoriasis: Data from a Large Single-Centre Registry and Review of the Literature.

Bazso A, Szodoray P, Szappanos A, Korda J, Palfi P, Kiss E Mediators Inflamm. 2015; 2015:657907.

PMID: 26339139 PMC: 4539075. DOI: 10.1155/2015/657907.

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice.

Zhu L, He Z, Wu F, Ding R, Jiang Q, Zhang J Cardiovasc Diabetol. 2014; 13:151.

PMID: 25391642 PMC: 4234834. DOI: 10.1186/s12933-014-0151-6.

Oxidative stress in cardiovascular inflammation: its involvement in autoimmune responses.

Profumo E, Buttari B, Rigano R Int J Inflam. 2011; 2011:295705.

PMID: 21755027 PMC: 3132615. DOI: 10.4061/2011/295705.

Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics.

Jan M, Meng S, Chen N, Mai J, Wang H, Yang X J Biomed Biotechnol. 2010; 2010:459798.

PMID: 20414374 PMC: 2858284. DOI: 10.1155/2010/459798.

References

Su J, Hua X, Concha H, Svenungsson E, Cederholm A, Frostegard J . Natural antibodies against phosphorylcholine as potential protective factors in SLE. Rheumatology (Oxford). 2008; 47(8):1144-50. DOI: 10.1093/rheumatology/ken120. View

Koizumi Y, Kurita-Ochiai T, Oguchi S, Yamamoto M . Nasal immunization with Porphyromonas gingivalis outer membrane protein decreases P. gingivalis-induced atherosclerosis and inflammation in spontaneously hyperlipidemic mice. Infect Immun. 2008; 76(7):2958-65. PMC: 2446728. DOI: 10.1128/IAI.01572-07. View

Conti F, Rezai S, Valesini G . Vaccination and autoimmune rheumatic diseases. Autoimmun Rev. 2008; 8(2):124-8. DOI: 10.1016/j.autrev.2008.07.007. View

Libby P . Inflammation in atherosclerosis. Nature. 2002; 420(6917):868-74. DOI: 10.1038/nature01323. View

SIEGLER P . Some immunological aspects of atherosclerosis. Rev Atheroscler (Paris). 1967; 9(1):Suppl 1:199+. View

Gaofu Q, Rongyue C, Dan M, Xiuyun Z, Xuejun W, Jie W . Asparaginase display of human cholesteryl ester transfer protein (CETP) B cell epitopes for inducing high titers of anti-CETP antibodies in vivo. Protein Pept Lett. 2006; 13(2):149-54. DOI: 10.2174/092986606775101689. View

Harats D, Yacov N, Gilburd B, Shoenfeld Y, George J . Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions. J Am Coll Cardiol. 2002; 40(7):1333-8. DOI: 10.1016/s0735-1097(02)02135-6. View

Naghavi M, Barlas Z, Siadaty S, Naguib S, Madjid M, Casscells W . Association of influenza vaccination and reduced risk of recurrent myocardial infarction. Circulation. 2000; 102(25):3039-45. DOI: 10.1161/01.cir.102.25.3039. View

Lamb D, Tickner M, Dreux A, El-Sankary W, Hourani S, Eales-Reynolds L . Impairment of vascular function following BCG immunisation is associated with immune responses to HSP-60 in the cholesterol-fed rabbit. Atherosclerosis. 2004; 172(1):13-20. DOI: 10.1016/j.atherosclerosis.2003.08.031. View

10.

Asztalos B, Schaefer E . HDL in atherosclerosis: actor or bystander?. Atheroscler Suppl. 2003; 4(1):21-9. DOI: 10.1016/s1567-5688(03)00006-0. View

11.

Madjid M, Naghavi M, Litovsky S, Casscells S . Influenza and cardiovascular disease: a new opportunity for prevention and the need for further studies. Circulation. 2003; 108(22):2730-6. DOI: 10.1161/01.CIR.0000102380.47012.92. View

12.

Tsonis I, Avrameas S, Moutsopoulos H . Autoimmunity and pathophysiology. J Autoimmun. 2007; 29(4):203-5. DOI: 10.1016/j.jaut.2007.07.009. View

13.

Ryan U, Rittershaus C . Vaccines for the prevention of cardiovascular disease. Vascul Pharmacol. 2006; 45(5):253-7. DOI: 10.1016/j.vph.2006.08.004. View

14.

Bassi N, Ghirardello A, Iaccarino L, Zampieri S, Rampudda M, Atzeni F . OxLDL/beta2GPI-anti-oxLDL/beta2GPI complex and atherosclerosis in SLE patients. Autoimmun Rev. 2007; 7(1):52-58. DOI: 10.1016/j.autrev.2007.06.003. View

15.

Shoenfeld Y, Selmi C, Zimlichman E, Gershwin M . The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun. 2008; 31(4):325-30. DOI: 10.1016/j.jaut.2008.08.004. View

16.

Rajaiah R, Moudgil K . Heat-shock proteins can promote as well as regulate autoimmunity. Autoimmun Rev. 2009; 8(5):388-93. PMC: 2668694. DOI: 10.1016/j.autrev.2008.12.004. View

17.

Sawayama Y, Tatsukawa M, Kikuchi K, Maeda S, Ohnishi H, Furusyo N . Effect on carotid atherosclerosis of probucol plus levofloxacin for Chlamydia pneumoniae infection. J Infect Chemother. 2007; 13(2):92-8. DOI: 10.1007/s10156-007-0510-2. View

18.

Schett G, Xu Q, Amberger A, van der Zee R, Recheis H, Willeit J . Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest. 1995; 96(6):2569-77. PMC: 185960. DOI: 10.1172/JCI118320. View

19.

Bixel M, Petri B, Khandoga A, Khandoga A, Wolburg-Buchholz K, Wolburg H . A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Blood. 2007; 109(12):5327-36. DOI: 10.1182/blood-2006-08-043109. View

20.

Nilsson J, Hansson G, Shah P . Immunomodulation of atherosclerosis: implications for vaccine development. Arterioscler Thromb Vasc Biol. 2004; 25(1):18-28. DOI: 10.1161/01.ATV.0000149142.42590.a2. View