Epigenetic Influences on Brain Development and Plasticity

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2009 Jun 24

PMID 19545993

Citations 131

Authors

Michela Fagiolini

Catherine L Jensen

Frances A Champagne

Affiliations

Soon will be listed here.

Abstract

A fine interplay exists between sensory experience and innate genetic programs leading to the sculpting of neuronal circuits during early brain development. Recent evidence suggests that the dynamic regulation of gene expression through epigenetic mechanisms is at the interface between environmental stimuli and long lasting molecular, cellular and complex behavioral phenotypes acquired during periods of developmental plasticity. Understanding these mechanisms may give insight into the formation of critical periods and provide new strategies for increasing plasticity and adaptive change in adulthood.

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