A Combinatorial Mechanism for Determining the Specificity of E2F Activation and Repression

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2009 Jun 23

PMID 19543322

Citations 24

Authors

J A Freedman

J T Chang

L Jakoi

J R Nevins

Affiliations

Soon will be listed here.

Abstract

Various studies have detailed the role of E2F proteins in both transcription activation and repression. Further study has shown that distinct promoter elements, but comprising the same E2F-recognition motif, confer positive or negative E2F control and that this reflects binding of either activator or repressor E2F proteins, respectively. We now show that the specificity of binding of an activator or repressor E2F protein is determined by adjacent sequences that bind a cooperating transcription factor. We propose that the functional E2F element is a module comprising not only the E2F-binding site but also the adjacent site for the cooperating transcription factor.

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