CD95, BIM and T Cell Homeostasis

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2009 Jun 23

PMID 19543226

Citations 102

Authors

Philippe Bouillet

Lorraine A OReilly

Affiliations

Soon will be listed here.

Abstract

The relative importance of the intrinsic and extrinsic apoptotic pathways in the control of haematopoietic cell homeostasis has been a matter of debate for many years. Cell death is omnipresent in this cellular compartment and ensures the removal of cells that are not properly equipped to assume their function as well as those that have assumed function but are no longer required. In this Review we focus on the roles of CD95 (also known as FAS) and BCL-2-interacting mediator of cell death (BIM), two major regulators of apoptosis in T cell homeostasis, with a particular emphasis on their cooperation in the shutdown of T cell responses.

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References

Bonfoco E, Stuart P, Brunner T, Lin T, Griffith T, Gao Y . Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells. Immunity. 1998; 9(5):711-20. DOI: 10.1016/s1074-7613(00)80668-8. View

Trambas C, Griffiths G . Delivering the kiss of death. Nat Immunol. 2003; 4(5):399-403. DOI: 10.1038/ni0503-399. View

Newton K, Harris A, Bath M, Smith K, Strasser A . A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 1998; 17(3):706-18. PMC: 1170420. DOI: 10.1093/emboj/17.3.706. View

Metcalf D . Lineage commitment in the progeny of murine hematopoietic preprogenitor cells: influence of thrombopoietin and interleukin 5. Proc Natl Acad Sci U S A. 1998; 95(11):6408-12. PMC: 27751. DOI: 10.1073/pnas.95.11.6408. View

Russell J, Rush B, Weaver C, Wang R . Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci U S A. 1993; 90(10):4409-13. PMC: 46520. DOI: 10.1073/pnas.90.10.4409. View

Vella A, Dow S, POTTER T, Kappler J, Marrack P . Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A. 1998; 95(7):3810-5. PMC: 19919. DOI: 10.1073/pnas.95.7.3810. View

Strasser A, Harris A, Huang D, Krammer P, Cory S . Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 1995; 14(24):6136-47. PMC: 394738. DOI: 10.1002/j.1460-2075.1995.tb00304.x. View

Mogil R, Radvanyi L, Miller R, Mills G, Theofilopoulos A, Green D . Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int Immunol. 1995; 7(9):1451-8. DOI: 10.1093/intimm/7.9.1451. View

Nagata S . Apoptosis by death factor. Cell. 1997; 88(3):355-65. DOI: 10.1016/s0092-8674(00)81874-7. View

10.

Brannan C, Copeland N, Jenkins N, Nagata S . Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 1992; 356(6367):314-7. DOI: 10.1038/356314a0. View

11.

Bouillet P, Purton J, Godfrey D, Zhang L, Coultas L, Puthalakath H . BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 2002; 415(6874):922-6. DOI: 10.1038/415922a. View

12.

von Boehmer H . Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol. 1990; 8:531-56. DOI: 10.1146/annurev.iy.08.040190.002531. View

13.

Kang T, Ben-Moshe T, Varfolomeev E, Pewzner-Jung Y, Yogev N, Jurewicz A . Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol. 2004; 173(5):2976-84. DOI: 10.4049/jimmunol.173.5.2976. View

14.

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D . ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death Differ. 2007; 14(5):1040-9. DOI: 10.1038/sj.cdd.4402101. View

15.

Oltersdorf T, Elmore S, Shoemaker A, Armstrong R, Augeri D, Belli B . An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005; 435(7042):677-81. DOI: 10.1038/nature03579. View

16.

Walsh C, Wen B, Chinnaiyan A, ORourke K, Dixit V, Hedrick S . A role for FADD in T cell activation and development. Immunity. 1998; 8(4):439-49. DOI: 10.1016/s1074-7613(00)80549-x. View

17.

Reap E, Felix N, Wolthusen P, Kotzin B, Cohen P, Eisenberg R . bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy. J Immunol. 1995; 155(11):5455-62. View

18.

Lenardo M . Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature. 1991; 353(6347):858-61. DOI: 10.1038/353858a0. View

19.

Strasser A, Jost P, Nagata S . The many roles of FAS receptor signaling in the immune system. Immunity. 2009; 30(2):180-92. PMC: 2956119. DOI: 10.1016/j.immuni.2009.01.001. View

20.

Kischkel F, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer P . Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995; 14(22):5579-88. PMC: 394672. DOI: 10.1002/j.1460-2075.1995.tb00245.x. View