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A New Borrelia Species Defined by Multilocus Sequence Analysis of Housekeeping Genes

Abstract

Analysis of Lyme borreliosis (LB) spirochetes, using a novel multilocus sequence analysis scheme, revealed that OspA serotype 4 strains (a rodent-associated ecotype) of Borrelia garinii were sufficiently genetically distinct from bird-associated B. garinii strains to deserve species status. We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes.

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References
1.
Attie O, Bruno J, Xu Y, Qiu D, Luft B, Qiu W . Co-evolution of the outer surface protein C gene (ospC) and intraspecific lineages of Borrelia burgdorferi sensu stricto in the northeastern United States. Infect Genet Evol. 2006; 7(1):1-12. DOI: 10.1016/j.meegid.2006.02.008. View

2.
Hanincova K, Taragelova V, Koci J, Schafer S, Hails R, Ullmann A . Association of Borrelia garinii and B. valaisiana with songbirds in Slovakia. Appl Environ Microbiol. 2003; 69(5):2825-30. PMC: 154513. DOI: 10.1128/AEM.69.5.2825-2830.2003. View

3.
Masuzawa T, Kharitonenkov I, Kadosaka T, Hashimoto N, Kudeken M, Takada N . Characterization of Borrelia burgdorferi sensu lato isolated in Moscow province--a sympatric region for Ixodes ricinus and Ixodes persulcatus. Int J Med Microbiol. 2005; 294(7):455-64. DOI: 10.1016/j.ijmm.2004.09.008. View

4.
Qiu W, Schutzer S, Bruno J, Attie O, Xu Y, Dunn J . Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. Proc Natl Acad Sci U S A. 2004; 101(39):14150-5. PMC: 521097. DOI: 10.1073/pnas.0402745101. View

5.
Huegli D, Hu C, Wilske B, Gern L . Apodemus species mice are reservoir hosts of Borrelia garinii OspA serotype 4 in Switzerland. J Clin Microbiol. 2002; 40(12):4735-7. PMC: 154586. DOI: 10.1128/JCM.40.12.4735-4737.2002. View