Autophagy, Immunity, and Microbial Adaptations

Overview

Journal Cell Host Microbe

Publisher Cell Press

Specialties Infectious Diseases
Microbiology

Date 2009 Jun 17

PMID 19527881

Citations 475

Authors

Vojo Deretic

Beth Levine

Affiliations

Soon will be listed here.

Abstract

Autophagy adjusts cellular biomass and function in response to diverse stimuli, including infection. Autophagy plays specific roles in shaping immune system development, fueling host innate and adaptive immune responses, and directly controlling intracellular microbes as a cell-autonomous innate defense. As an evolutionary counterpoint, intracellular pathogens have evolved to block autophagic microbicidal defense and subvert host autophagic responses for their survival or growth. The ability of eukaryotic pathogens to deploy their own autophagic machinery may also contribute to microbial pathogenesis. Thus, a complex interplay between autophagy and microbial adaptations against autophagy governs the net outcome of host-microbe encounters.

Citing Articles

BCL2 regulates antibacterial autophagy in the intestinal epithelium.

Li Y, Bel S, Benjamin J, Ruhn K, Hassell B, Behrendt C Proc Natl Acad Sci U S A. 2024; 121(49):e2410205121.

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Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound.

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SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD.

Lin S, Qiu X, Fu X, Zhang S, Tang C, Kuang J Mol Ther. 2024; 33(1):279-296.

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ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B.

Yang L, Liu X, Zhen L, Liu Y, Wu L, Xu W BMC Med. 2024; 22(1):521.

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