Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots

Overview

Journal Open Neuroimag J

Publisher Bentham Open

Date 2009 Jun 16

PMID 19526075

Citations 6

Authors

Dionyssios Mintzopoulos

Azadeh Khanicheh

Angelos A Konstas

Loukas G Astrakas

Aneesh B Singhal

Michael A Moskowitz

Bruce R Rosen

A Aria Tzika

Affiliations

Soon will be listed here.

Abstract

We monitored brain activation after chronic stroke by combining functional magnetic resonance imaging (fMRI) with a novel MR-compatible, hand-induced, robotic device (MR_CHIROD). We evaluated 60 fMRI datasets on a 3 T MR system from five right-handed patients with left-sided stroke >/=6 months prior and mild to moderate hemiparesis. Patients trained the paretic right hand at approximately 75% of maximum strength with an exercise ball for 1 hour/day, 3 days/week for 4 weeks. Multi-level fMRI data were acquired before, during training, upon completion of training, and after a non-training period using parallel imaging employing GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) while the participant used the MR_CHIROD. Training increased the number of activated sensorimotor cortical voxels, indicating functional cortical plasticity in chronic stroke patients. The effect persisted four weeks after training completion, indicating the potential of rehabilitation in inducing cortical plasticity in chronic stroke patients.

Citing Articles

Peak Activation Shifts in the Sensorimotor Cortex of Chronic Stroke Patients Following Robot-assisted Rehabilitation Therapy.

Astrakas L, Li S, Ottensmeyer M, Pusatere C, Moskowitz M, Tzika A Open Neuroimag J. 2021; 14:8-15.

PMID: 34434290 PMC: 8384467. DOI: 10.2174/1874440002114010008.

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits.

Ottensmeyer M, Li S, Novi G, Tzika A J Vis Exp. 2019; (153).

PMID: 31814610 PMC: 7147332. DOI: 10.3791/59420.

Recovery Potential After Acute Stroke.

Seitz R, Donnan G Front Neurol. 2015; 6:238.

PMID: 26617568 PMC: 4641432. DOI: 10.3389/fneur.2015.00238.

fMRI as a molecular imaging procedure for the functional reorganization of motor systems in chronic stroke.

Lazaridou A, Astrakas L, Mintzopoulos D, Khanchiceh A, Singhal A, Moskowitz M Mol Med Rep. 2013; 8(3):775-9.

PMID: 23900349 PMC: 3782530. DOI: 10.3892/mmr.2013.1603.

Functional MRI using robotic MRI compatible devices for monitoring rehabilitation from chronic stroke in the molecular medicine era (Review).

Astrakas L, Naqvi S, Kateb B, Tzika A Int J Mol Med. 2012; 29(6):963-73.

PMID: 22426741 PMC: 3981645. DOI: 10.3892/ijmm.2012.942.

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