Novel Imaging Provides New Insights into Mechanisms of Oxygen Transport in Tumors

Overview

Journal Curr Mol Med

Publisher Bentham Science Publishers

Specialty Molecular Biology

Date 2009 Jun 13

PMID 19519401

Citations 25

Authors

Matthew E Hardee

Mark W Dewhirst

Nikita Agarwal

Brian S Sorg

Affiliations

Soon will be listed here.

Abstract

Hypoxia is a common feature of solid tumors, and abnormal tumor oxygen transport is a key factor in the imbalance between tumor oxygen supply and demand. Novel advanced imaging techniques can enable new insights into the complexities of tumor oxygen transport and hypoxia that were not previously known or fully appreciated. In this paper, we document new insights into tumor oxygen transport enabled by spectral imaging of microvascular hemoglobin saturation.

Citing Articles

The Complexity of Malignant Glioma Treatment.

Kampers L, Metselaar D, Vinci M, Scirocchi F, Veldhuijzen van Zanten S, Eyrich M Cancers (Basel). 2025; 17(5).

PMID: 40075726 PMC: 11899524. DOI: 10.3390/cancers17050879.

Clinicopathological significance of sulfite oxidase expression in surgically resected lung adenocarcinoma.

Tokisawa S, Kondo R, Nakayama M, Ogasawara S, Murotani K, Mitsuoka M Med Mol Morphol. 2024; .

PMID: 39652223 DOI: 10.1007/s00795-024-00413-z.

Travelling under pressure - hypoxia and shear stress in the metastatic journey.

Ildiz E, Gvozdenovic A, Kovacs W, Aceto N Clin Exp Metastasis. 2023; 40(5):375-394.

PMID: 37490147 PMC: 10495280. DOI: 10.1007/s10585-023-10224-8.

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development.

Ling R, Chen G, Tang X, Liu N, Zhou Y, Chen D Discov Oncol. 2022; 13(1):58.

PMID: 35798917 PMC: 9263018. DOI: 10.1007/s12672-022-00521-1.

Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path.

Iessi E, Vona R, Cittadini C, Matarrese P Biomedicines. 2021; 9(12).

PMID: 34944758 PMC: 8698563. DOI: 10.3390/biomedicines9121942.

References

Vaupel P, Kallinowski F, Okunieff P . Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 1989; 49(23):6449-65. View

Smith Jr R, Aapro M, Ludwig H, Pinter T, Smakal M, Ciuleanu T . Darbepoetin alpha for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter, randomized, double-blind, placebo-controlled study. J Clin Oncol. 2008; 26(7):1040-50. DOI: 10.1200/JCO.2007.14.2885. View

Colantuoni A, Bertuglia S, Intaglietta M . Microvascular vasomotion: origin of laser Doppler flux motion. Int J Microcirc Clin Exp. 1994; 14(3):151-8. DOI: 10.1159/000178823. View

Henke M, Laszig R, Rube C, Schafer U, Haase K, Schilcher B . Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet. 2003; 362(9392):1255-60. DOI: 10.1016/S0140-6736(03)14567-9. View

Zeman E, Calkins D, Cline J, Thrall D, Raleigh J . The relationship between proliferative and oxygenation status in spontaneous canine tumors. Int J Radiat Oncol Biol Phys. 1993; 27(4):891-8. DOI: 10.1016/0360-3016(93)90465-8. View

Hardee M, Arcasoy M, Blackwell K, Kirkpatrick J, Dewhirst M . Erythropoietin biology in cancer. Clin Cancer Res. 2006; 12(2):332-9. DOI: 10.1158/1078-0432.CCR-05-1771. View

Leyland-Jones B, Semiglazov V, Pawlicki M, Pienkowski T, Tjulandin S, Manikhas G . Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol. 2005; 23(25):5960-72. DOI: 10.1200/JCO.2005.06.150. View

Cardenas-Navia L, Richardson R, Dewhirst M . Targeting the molecular effects of a hypoxic tumor microenvironment. Front Biosci. 2007; 12:4061-78. DOI: 10.2741/2372. View

Rofstad E, Sundfor K, Lyng H, Trope C . Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer. 2000; 83(3):354-9. PMC: 2374576. DOI: 10.1054/bjoc.2000.1266. View

10.

Dewhirst M . Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res. 2007; 67(3):854-5. DOI: 10.1158/0008-5472.CAN-06-4744. View

11.

Braun R, Lanzen J, Dewhirst M . Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am J Physiol. 1999; 277(2):H551-68. DOI: 10.1152/ajpheart.1999.277.2.H551. View

12.

Sorg B, Hardee M, Agarwal N, Moeller B, Dewhirst M . Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. J Biomed Opt. 2008; 13(1):014026. DOI: 10.1117/1.2837439. View

13.

Blackwell K, Kirkpatrick J, Snyder S, Broadwater G, Farrell F, Jolliffe L . Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. Cancer Res. 2003; 63(19):6162-5. View

14.

Chaplin D, Hill S . Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours. Br J Cancer. 1995; 71(6):1210-3. PMC: 2033835. DOI: 10.1038/bjc.1995.235. View

15.

Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P . Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996; 56(19):4509-15. View

16.

Nicklee T, Hedley D . Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts. Br J Cancer. 1999; 81(6):989-93. PMC: 2362959. DOI: 10.1038/sj.bjc.6690797. View

17.

Lanzen J, Braun R, Klitzman B, Brizel D, Secomb T, Dewhirst M . Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 2006; 66(4):2219-23. DOI: 10.1158/0008-5472.CAN-03-2958. View

18.

Li C, Shan S, Huang Q, Braun R, Lanzen J, Hu K . Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. J Natl Cancer Inst. 2000; 92(2):143-7. DOI: 10.1093/jnci/92.2.143. View

19.

Hardee M, Cao Y, Fu P, Jiang X, Zhao Y, Rabbani Z . Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PLoS One. 2007; 2(6):e549. PMC: 1891087. DOI: 10.1371/journal.pone.0000549. View

20.

Kimura H, Braun R, Ong E, Hsu R, Secomb T, Papahadjopoulos D . Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res. 1996; 56(23):5522-8. View