A Novel Laparoscopic Device for Measuring Gastrointestinal Slow-wave Activity

Overview

Journal Surg Endosc

Publisher Springer

Specialties Gastroenterology
General Surgery
Radiology

Date 2009 May 26

PMID 19466491

Citations 21

Authors

Gregory OGrady

Peng Du

John U Egbuji

Wim J E P Lammers

Athiq Wahab

Andrew J Pullan

Leo K Cheng

John A Windsor

Affiliations

Soon will be listed here.

Abstract

Background: A periodic electrical activity, termed "slow waves", coordinates gastrointestinal contractions. Slow-wave dysrhythmias are thought to contribute to dysmotility syndromes such as postoperative gastroparesis, but the clinical significance of these dysrhythmias remains poorly defined. Electrogastrography (EGG) has been unable to characterize dsyrhythmic activity reliably, and the most accurate method for evaluating slow waves is to record directly from the surface of the target organ. This study presents a novel laparoscopic device for recording serosal slow-wave activity, together with its validation.

Methods: The novel device consists of a shaft (diameter, 4 mm; length, 300 mm) and a flexible connecting cable. It contains four individual electrodes and is fully shielded. Validation was performed by comparing slow-wave recordings from the laparoscopic device with those from a standard electrode platform in an open-abdomen porcine model. An intraoperative human trial of the device also was performed by recording activity from the gastric antrum of a patient undergoing a laparoscopic cholecystectomy.

Results: Slow-wave amplitudes were similar between the laparoscopic device and the standard recording platform (mean 0.38 ± 0.03 mV vs range 0.36-0.38 ± 0.03 mV) (p = 0.94). The signal-to-noise ratio (SNR) also was similar between the two types of electrodes (13.7 dB vs 12.6 dB). High-quality antral slow-wave recordings were achieved in the intraoperative human trial (amplitude, 0.41 ± 0.04 mV; SNR, 12.6 dB), and an activation map was constructed showing normal aboral slow-wave propagation at a velocity of 6.3 ± 0.9 mm/s.

Conclusions: The novel laparoscopic device achieves high-quality serosal slow-wave recordings. It is easily deployable and atraumatic. It is anticipated that this device will aid in the clinical investigation of normal and dsyrhythmic slow-wave activity. In particular, it offers new potential for investigating the effect of surgical procedures on slow-wave activity.

Citing Articles

Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract.

Ding F, Guo R, Cui Z, Hu H, Zhao G World J Gastrointest Surg. 2022; 14(6):544-555.

PMID: 35979419 PMC: 9258241. DOI: 10.4240/wjgs.v14.i6.544.

A novel retractable laparoscopic device for mapping gastrointestinal slow wave propagation patterns.

Berry R, Paskaranandavadivel N, Du P, Trew M, OGrady G, Windsor J Surg Endosc. 2016; 31(1):477-486.

PMID: 27129554 PMC: 5086319. DOI: 10.1007/s00464-016-4936-4.

Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity.

Paskaranandavadivel N, OGrady G, Cheng L IEEE Trans Biomed Eng. 2016; 64(1):166-172.

PMID: 27071158 PMC: 5292208. DOI: 10.1109/TBME.2016.2548940.

A physiome interoperability roadmap for personalized drug development.

Thomas S, Wolstencroft K, de Bono B, Hunter P Interface Focus. 2016; 6(2):20150094.

PMID: 27051513 PMC: 4759752. DOI: 10.1098/rsfs.2015.0094.

Noninvasive biomagnetic detection of intestinal slow wave dysrhythmias in chronic mesenteric ischemia.

Somarajan S, Muszynski N, Cheng L, Bradshaw L, Naslund T, Richards W Am J Physiol Gastrointest Liver Physiol. 2015; 309(1):G52-8.

PMID: 25930082 PMC: 4491509. DOI: 10.1152/ajpgi.00466.2014.

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