Gastric Arrhythmias in Gastroparesis: Low- and High-resolution Mapping of Gastric Electrical Activity

Overview

Journal Gastroenterol Clin North Am

Specialty Gastroenterology

Date 2015 Feb 11

PMID 25667031

Citations 14

Authors

Gregory OGrady

Thomas L Abell

Affiliations

Soon will be listed here.

Abstract

Gastric arrhythmias occur in gastroparesis but their significance is debated. An improved understanding is currently emerging, including newly-defined histopathologic abnormalities in gastroparesis. In particular, the observation that interstitial cells of Cajal are depleted and injured provides mechanisms for arrhythmogenesis in gastroparesis. Electrogastrography has been the dominant clinical method of arrhythmia analysis, but is limited by summative nature, low signal quality, and incomplete sensitivity and specificity. Recently, high-resolution (HR; multi-electrode) mapping has emerged, providing superior spatial data on arrhythmic patterns and mechanisms. However, HR mapping is invasive, and low-resolution approaches are being assessed as bridging techniques until endoscopic mapping is achieved.

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