Autophagy is Required for Extension of Yeast Chronological Life Span by Rapamycin

Overview

Journal Autophagy

Specialty Cell Biology

Date 2009 May 22

PMID 19458476

Citations 93

Authors

Ashley L Alvers

Michael S Wood

Doreen Hu

Amelia C Kaywell

William A Dunn Jr

John P Aris

Affiliations

Soon will be listed here.

Abstract

Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.

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