Midline Governs Axon Pathfinding by Coordinating Expression of Two Major Guidance Systems

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2009 May 20

PMID 19451216

Citations 16

Authors

Qing-Xin Liu

Masaki Hiramoto

Hitoshi Ueda

Takashi Gojobori

Yasushi Hiromi

Susumu Hirose

Affiliations

Soon will be listed here.

Abstract

Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that Drosophila T-box protein Midline controls expression of genes encoding components of two major guidance systems: Frazzled, ROBO, and Slit. In midline mutant, expression of all these molecules are reduced, resulting in severe axon guidance defects, whereas misexpression of Midline induces their expression. Midline is present on the promoter regions of these genes, indicating that Midline controls transcription directly. We propose that Midline controls axon pathfinding through coordinating the two guidance systems.

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