» Articles » PMID: 19448972

Nicotinamide/nicotinic Acid Mononucleotide Adenylyltransferase, New Insights into an Ancient Enzyme

Overview
Publisher Springer
Specialty Biology
Date 2009 May 19
PMID 19448972
Citations 42
Authors
Affiliations
Soon will be listed here.
Abstract

Nicotinamide/nicotinic acid mononucleotide adenylyltransferase (NMNAT) has long been known as the master enzyme in NAD biosynthesis in living organisms. A burst of investigations on NMNAT, going beyond enzymology, have paralleled increasing discoveries of key roles played by NAD homeostasis in a number or patho-physiological conditions. The availability of in-depth kinetics and structural enzymology analyses carried out on NMNATs from different organisms offer a powerful tool for uncovering fascinating evolutionary relationships. On the other hand, additional functions featuring NMNAT have emerged from investigations aimed at unraveling the molecular mechanisms responsible for complex biological phenomena such as neurodegeneration. NMNAT appears to be a multifunctional protein that sits both at the core of central metabolism and at a crossroads of multiple cellular processes. The resultant wealth of biochemical data has built a robust framework upon which design of NMNAT activators, inhibitors or enzyme variants of potential medical interest can be based.

Citing Articles

SNF7 Presents Excellent Antibacteria and Anti-Inflammation Properties in Mouse Diarrhea Induced by .

Feng M, Cheng J, Su Y, Tong J, Wen X, Jin T Int J Mol Sci. 2025; 25(24.

PMID: 39769422 PMC: 11728428. DOI: 10.3390/ijms252413660.


Local translatome sustains synaptic function in impaired Wallerian degeneration.

Paglione M, Restivo L, Zakhia S, Llobet Rosell A, Terenzio M, Neukomm L EMBO Rep. 2024; 26(1):61-83.

PMID: 39482489 PMC: 11724096. DOI: 10.1038/s44319-024-00301-8.


Interpretation of the effects of rumen acidosis on the gut microbiota and serum metabolites in calves based on 16S rDNA sequencing and non-target metabolomics.

Wu F, Ji P, Yang H, Zhu X, Wu X Front Cell Infect Microbiol. 2024; 14:1427763.

PMID: 39006744 PMC: 11239342. DOI: 10.3389/fcimb.2024.1427763.


Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.

Hasegawa K, Tamaki M, Sakamaki Y, Wakino S Int J Mol Sci. 2024; 25(12).

PMID: 38928090 PMC: 11204038. DOI: 10.3390/ijms25126384.


Untargeted metabonomics and TLR4/ NF-κB signaling pathway analysis reveals potential mechanism of action of polysaccharide in nonalcoholic fatty liver disease.

Deng G, Zhao C, Cai X, Zhang X, Ma M, Lv J Front Pharmacol. 2024; 15:1374158.

PMID: 38887554 PMC: 11180771. DOI: 10.3389/fphar.2024.1374158.


References
1.
Perry V, Brown M, Lunn E . Very Slow Retrograde and Wallerian Degeneration in the CNS of C57BL/Ola Mice. Eur J Neurosci. 1991; 3(1):102-5. DOI: 10.1111/j.1460-9568.1991.tb00815.x. View

2.
Holm L, Sander C . New structure--novel fold?. Structure. 1997; 5(2):165-71. DOI: 10.1016/s0969-2126(97)00176-7. View

3.
Magrane J, Smith R, Walsh K, Querfurth H . Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons. J Neurosci. 2004; 24(7):1700-6. PMC: 6730449. DOI: 10.1523/JNEUROSCI.4330-03.2004. View

4.
Raffaelli N, Sorci L, Amici A, Emanuelli M, Mazzola F, Magni G . Identification of a novel human nicotinamide mononucleotide adenylyltransferase. Biochem Biophys Res Commun. 2002; 297(4):835-40. DOI: 10.1016/s0006-291x(02)02285-4. View

5.
Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R . Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice. J Cell Biol. 2009; 184(4):491-500. PMC: 2654131. DOI: 10.1083/jcb.200807175. View