Formulation of New Algorithmics for MiRNAs

Overview

Journal Open Virol J

Publisher Bentham Open

Date 2009 May 15

PMID 19440463

Citations 2

Authors

Yoichi Robertus Fujii

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs) are a class of small RNAs, 21-25 nucleotides (nts) long with single-stranded RNA. miRNA targets the sequences of messenger RNA (mRNA) through incomplete base-pairing of the target sequence. The incomplete pairing of miRNA to mRNA triggers either translational repression or epigenetically mediated transcriptional gene silencing (TGS). miRNA and RNA silencing in mammalian cells may participate in natural ecological interactions and miRNA itself should contain the original information that is required to control viral proliferation, according to the hypothesis of RNA waves. While the hypothesis involves so-called resident and genomic miRNA as the genetic information, resident miRNAs may evolve and jump into other RNAs, and then become genomic miRNAs. Thus, the inheritable character may be acquired by both types of miRNAs. It is reasonable to believe that preparations of new algorithmics models for the flow of miRNAs may provide an opportunity to overcome the acquired immunodeficiency syndrome (AIDS) pandemic.

Citing Articles

RNA Genes: Retroelements and Virally Retroposable microRNAs in Human Embryonic Stem Cells.

Fujii Y Open Virol J. 2010; 4:63-75.

PMID: 20835360 PMC: 2936035. DOI: 10.2174/1874357901004010063.

Oncoviruses and Pathogenic MicroRNAs in Humans.

Fujii Y Open Virol J. 2009; 3:37-51.

PMID: 19920887 PMC: 2778015. DOI: 10.2174/1874357900903010037.

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