RNA Genes: Retroelements and Virally Retroposable MicroRNAs in Human Embryonic Stem Cells

Overview

Journal Open Virol J

Publisher Bentham Open

Date 2010 Sep 14

PMID 20835360

Citations 4

Authors

Yoichi R Fujii

Affiliations

Soon will be listed here.

Abstract

Embryonic stem cells (ESCs) are capable of undergoing self-renewal, and their developmental ability is known as the stemness. Recently, microRNAs (miRNAs) as regulators have been isolated from ESCs. Although Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) are essential factors for the biogeneration of miRNA, Dicer-knockout (KO) ESCs have showed to fail to express differentiation markers and DGCR8-KO ESCs have showed to be arrest in the G1 phase. Furthermore, Dicer-KO ESCs lost the ability to epigenetically silence retroelemtns (REs). REs are expressed and transposed in ESCs, whose transcripts control expression of miRNAs, and their transposable retroelement (TE) expression is, therefore related to ESC proliferation and differentiation, suggesting that the interplay between miRNAs and REs may have a deep responsibility for the stemness including a short G1/S transition and for RE regulation in ESCs.

Citing Articles

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References

Jaenisch R, Young R . Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 2008; 132(4):567-82. PMC: 4142810. DOI: 10.1016/j.cell.2008.01.015. View

Cui X, Zhang D, Ko Y, Kim N . Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos. Biochem Biophys Res Commun. 2009; 379(2):390-4. DOI: 10.1016/j.bbrc.2008.12.148. View

Borchert G, Lanier W, Davidson B . RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol. 2006; 13(12):1097-101. DOI: 10.1038/nsmb1167. View

Yamamoto T, Samri A, Marcelin A, Mitsuki Y, Vincent C, Autran B . Effect of lentivirus encoding HIV-1 Nef-U3 shRNA on the function of HIV-specific memory CD4(+) T cells in patients with chronic HIV-1 infection. AIDS. 2009; 23(17):2265-75. DOI: 10.1097/QAD.0b013e328332817c. View

Alexiou P, Maragkakis M, Papadopoulos G, Reczko M, Hatzigeorgiou A . Lost in translation: an assessment and perspective for computational microRNA target identification. Bioinformatics. 2009; 25(23):3049-55. DOI: 10.1093/bioinformatics/btp565. View

Wilson K, Venkatasubrahmanyam S, Jia F, Sun N, Butte A, Wu J . MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev. 2009; 18(5):749-58. PMC: 3135181. DOI: 10.1089/scd.2008.0247. View

Campbell K, McWhir J, Ritchie W, Wilmut I . Sheep cloned by nuclear transfer from a cultured cell line. Nature. 1996; 380(6569):64-6. DOI: 10.1038/380064a0. View

Viswanathan S, Powers J, Einhorn W, Hoshida Y, Ng T, Toffanin S . Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009; 41(7):843-8. PMC: 2757943. DOI: 10.1038/ng.392. View

Kikuchi K, Fukuda M, Ito T, Inoue M, Yokoi T, Chiku S . Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. Nucleic Acids Res. 2009; 37(15):4987-5000. PMC: 2731886. DOI: 10.1093/nar/gkp426. View

10.

Fujii Y . Formulation of New Algorithmics for miRNAs. Open Virol J. 2009; 2:37-43. PMC: 2678821. DOI: 10.2174/1874357900802010037. View

11.

Valeri N, Vannini I, Fanini F, Calore F, Adair B, Fabbri M . Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation. Mamm Genome. 2009; 20(9-10):573-80. DOI: 10.1007/s00335-009-9206-5. View

12.

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R . DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007; 39(3):380-5. PMC: 3008549. DOI: 10.1038/ng1969. View

13.

Viswanathan S, Daley G, Gregory R . Selective blockade of microRNA processing by Lin28. Science. 2008; 320(5872):97-100. PMC: 3368499. DOI: 10.1126/science.1154040. View

14.

Wehn P, Harrington P, Eksterowicz J . Facile synthesis of substituted 5-amino- and 3-amino-1,2,4-thiadiazoles from a common precursor. Org Lett. 2009; 11(24):5666-9. DOI: 10.1021/ol902371y. View

15.

Saito Y, Suzuki H, Tsugawa H, Nakagawa I, Matsuzaki J, Kanai Y . Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene. 2009; 28(30):2738-44. DOI: 10.1038/onc.2009.140. View

16.

Landais S, Landry S, Legault P, Rassart E . Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res. 2007; 67(12):5699-707. DOI: 10.1158/0008-5472.CAN-06-4478. View

17.

Pesce M, Gross M, Scholer H . In line with our ancestors: Oct-4 and the mammalian germ. Bioessays. 1998; 20(9):722-32. DOI: 10.1002/(SICI)1521-1878(199809)20:9<722::AID-BIES5>3.0.CO;2-I. View

18.

Marion R, Strati K, Li H, Murga M, Blanco R, Ortega S . A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature. 2009; 460(7259):1149-53. PMC: 3624089. DOI: 10.1038/nature08287. View

19.

le Sage C, Nagel R, Egan D, Schrier M, Mesman E, Mangiola A . Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J. 2007; 26(15):3699-708. PMC: 1949005. DOI: 10.1038/sj.emboj.7601790. View

20.

Lengner C, Camargo F, Hochedlinger K, Welstead G, Zaidi S, Gokhale S . Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell. 2007; 1(4):403-15. PMC: 2151746. DOI: 10.1016/j.stem.2007.07.020. View