Established Prostate Cancer Susceptibility Variants Are Not Associated with Disease Outcome

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2009 May 9

PMID 19423541

Citations 23

Authors

Fredrik E Wiklund

Hans-Olov Adami

Sigun L Zheng

Par Stattin

William B Isaacs

Henrik Gronberg

Jianfeng Xu

Affiliations

Soon will be listed here.

Abstract

Recent genome-wide association studies have been successful in identifying common sequence variants associated with prostate cancer risk; however, their importance in prostate cancer prognosis remains unknown. To assess confirmed prostate cancer susceptibility variants with prostate cancer prognosis, we genotyped 16 established susceptibility variants in a Swedish cohort of 2,875 prostate cancer cases, ascertained between 2001 and 2003, with complete follow-up regarding vital status through January 2008. Cox regression models, adjusted for age, clinical stage, pathologic grade, nodal or distant metastases, and diagnostic serum levels of prostate-specific antigen level, were used to assess association between risk variants and prostate cancer-specific survival. During follow-up, 626 men died, and of those, 440 had prostate cancer classified as their underlying cause of death. We found no association between any of the explored sequence variants and prostate cancer-specific mortality, either in exploring individual variants or in assessing the cumulative effect of all variants. We conclude that hitherto established prostate cancer susceptibility variants are not associated with the lethal potential of prostate cancer.

Citing Articles

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References

Severi G, Hayes V, Padilla E, English D, Southey M, Sutherland R . The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2007; 16(3):610-2. DOI: 10.1158/1055-9965.EPI-06-0872. View

Haiman C, Patterson N, Freedman M, Myers S, Pike M, Waliszewska A . Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007; 39(5):638-44. PMC: 2638766. DOI: 10.1038/ng2015. View

Schumacher F, Feigelson H, Cox D, Haiman C, Albanes D, Buring J . A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res. 2007; 67(7):2951-6. DOI: 10.1158/0008-5472.CAN-06-3591. View

Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson J, Thorleifsson G, Manolescu A . Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007; 39(8):977-83. DOI: 10.1038/ng2062. View

Gudmundsson J, Sulem P, Rafnar T, Bergthorsson J, Manolescu A, Gudbjartsson D . Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008; 40(3):281-3. PMC: 3598012. DOI: 10.1038/ng.89. View

Sun J, Purcell L, Gao Z, Isaacs S, Wiley K, Hsu F . Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans. Prostate. 2008; 68(7):691-7. PMC: 3176499. DOI: 10.1002/pros.20754. View

Suuriniemi M, Agalliu I, Schaid D, Johanneson B, McDonnell S, Iwasaki L . Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epidemiol Biomarkers Prev. 2007; 16(4):809-14. DOI: 10.1158/1055-9965.EPI-06-1049. View

Freedman M, Haiman C, Patterson N, McDonald G, Tandon A, Waliszewska A . Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A. 2006; 103(38):14068-73. PMC: 1599913. DOI: 10.1073/pnas.0605832103. View

Eeles R, Kote-Jarai Z, Giles G, Olama A, Guy M, Jugurnauth S . Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008; 40(3):316-21. DOI: 10.1038/ng.90. View

10.

Johansson J, Andren O, Andersson S, Dickman P, Holmberg L, Magnuson A . Natural history of early, localized prostate cancer. JAMA. 2004; 291(22):2713-9. DOI: 10.1001/jama.291.22.2713. View

11.

Hartman M, Lindstrom L, Dickman P, Adami H, Hall P, Czene K . Is breast cancer prognosis inherited?. Breast Cancer Res. 2007; 9(3):R39. PMC: 1929105. DOI: 10.1186/bcr1737. View

12.

Lindstrom L, Hall P, Hartman M, Wiklund F, Gronberg H, Czene K . Familial concordance in cancer survival: a Swedish population-based study. Lancet Oncol. 2007; 8(11):1001-6. DOI: 10.1016/S1470-2045(07)70282-6. View

13.

Amundadottir L, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson B . A common variant associated with prostate cancer in European and African populations. Nat Genet. 2006; 38(6):652-8. DOI: 10.1038/ng1808. View

14.

Schraudenbach P, Bermejo C . Management of the complications of radical prostatectomy. Curr Urol Rep. 2007; 8(3):197-202. DOI: 10.1007/s11934-007-0006-8. View

15.

Robbins C, Torres J, Hooker S, Bonilla C, Hernandez W, Candreva A . Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus. Genome Res. 2007; 17(12):1717-22. PMC: 2099580. DOI: 10.1101/gr.6782707. View

16.

Wang L, McDonnell S, Slusser J, Hebbring S, Cunningham J, Jacobsen S . Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Res. 2007; 67(7):2944-50. DOI: 10.1158/0008-5472.CAN-06-3186. View

17.

Gudmundsson J, Sulem P, Manolescu A, Amundadottir L, Gudbjartsson D, Helgason A . Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet. 2007; 39(5):631-7. DOI: 10.1038/ng1999. View

18.

Thomas G, Jacobs K, Yeager M, Kraft P, Wacholder S, Orr N . Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008; 40(3):310-5. DOI: 10.1038/ng.91. View

19.

Duggan D, Zheng S, Knowlton M, Benitez D, Dimitrov L, Wiklund F . Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst. 2007; 99(24):1836-44. DOI: 10.1093/jnci/djm250. View

20.

Zheng S, Sun J, Cheng Y, Li G, Hsu F, Zhu Y . Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans. J Natl Cancer Inst. 2007; 99(20):1525-33. DOI: 10.1093/jnci/djm169. View