Asymmetric Synthesis of (+)-Iso-6-Cassine Via Stereoselective Intramolecular Amidomercuration

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2009 May 1

PMID 19404485

Citations 2

Authors

Satwinder Singh

Om V Singh

Hyunsoo Han

Affiliations

Soon will be listed here.

Abstract

The first asymmetric synthesis of (+)-iso-6-cassine is described. Lipase-catalyzed resolution, enantioselective Overman rearrangement, and diastereoselective intramolecular amidomercuration were used for the installation of the three stereocenters in (+)-iso-6-cassine, and cross-metathesis was employed for the attachment of the side-chain.

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