Adiposity in Relation to Colorectal Adenomas and Hyperplastic Polyps in Women

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 2009 Apr 24

PMID 19387851

Citations 5

Authors

Michael F Leitzmann

Andrew Flood

Leah M Ferrucci

Philip Schoenfeld

Brooks Cash

Arthur Schatzkin

Amanda J Cross

Affiliations

Soon will be listed here.

Abstract

Objective: To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps.

Methods: We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps.

Results: We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41-5.72).

Conclusions: Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer.

Citing Articles

Prevalence and risk factors of asymptomatic colorectal polyps in taiwan.

Wang F, Hsu P, Chuang H, Tu M, Mar G, King T Gastroenterol Res Pract. 2014; 2014:985205.

PMID: 25050119 PMC: 4094704. DOI: 10.1155/2014/985205.

BMI and the risk of colorectal adenoma in African-Americans.

Ashktorab H, Paydar M, Yazdi S, Namin H, Sanderson A, Begum R Obesity (Silver Spring). 2014; 22(5):1387-91.

PMID: 24519988 PMC: 4008675. DOI: 10.1002/oby.20702.

Association between Obesity, Serum Lipids, and Colorectal Polyps in Old Chinese People.

Yang W, Chang Y, Huang H, Wang Y, Yu X Gastroenterol Res Pract. 2013; 2013:931084.

PMID: 24198829 PMC: 3806499. DOI: 10.1155/2013/931084.

Obesity, metabolic factors, and colorectal adenomas: a retrospective study in a racially diverse New York State Hospital.

Lipka S, Zheng X, Hurtado-Cordovi J, Singh J, Levine E, Vlacancich R J Gastrointest Cancer. 2013; 44(3):270-6.

PMID: 23307188 DOI: 10.1007/s12029-013-9476-8.

Lifestyle factors and their combined impact on the risk of colorectal polyps.

Fu Z, Shrubsole M, Smalley W, Wu H, Chen Z, Shyr Y Am J Epidemiol. 2012; 176(9):766-76.

PMID: 23079606 PMC: 3571253. DOI: 10.1093/aje/kws157.

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