Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse
Overview
Authors
Affiliations
In a carcinogenicity study, a neuronal tumor in the cranial cavity was observed in a 110-week-old female B6C3F1 mouse. At necropsy, the tumor was seen at the site of the pituitary gland. Histologically, the tumor consisted of well-differentiated ganglion cells, nerve fiber/neuropil-like elements and ganglion-like cells. The tumor was composed mainly of ganglion-like cells, which were arranged in solid sheets interspersed with thin fibrovascular stroma. Nissl substance was detected at the margin in the cytoplasm of well-differentiated ganglion cells, and nerve fibers were identified by the Kluever-Barrera method. Immunohistochemically, the well-differentiated ganglion cells were positive for S-100, neurofilament protein (NF), neuron-specific enolase (NSE), synaptophysin, and chromogranin A. The nerve fiber/neuropil-like elements were positive for S-100, NF, NSE, and glial fibrillary acidic protein (GFAP), and the ganglion-like cells were strongly positive only for NSE and synaptophysin. On the other hand, there were no pituitary cells, such as prolactin-positive or adrenocorticotropic hormone (ACTH)-positive cells in the tumor tissue. Detailed histopathological examination suggested that the tumor might be a ganglioneuroma arising from the trigeminal ganglion. This report provides additional histopathological evidence of peripheral nerve neoplasms in mice.
Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.
Brandli-Baiocco A, Balme E, Bruder M, Chandra S, Hellmann J, Hoenerhoff M J Toxicol Pathol. 2018; 31(3 Suppl):1S-95S.
PMID: 30158740 PMC: 6108091. DOI: 10.1293/tox.31.1S.
Williams A, Doherty E, Hart M, Grider D Case Rep Med. 2018; 2018:4319818.
PMID: 29770149 PMC: 5889855. DOI: 10.1155/2018/4319818.
Adult hippocampal ganglioneuroblastoma: Case report and literature review.
Yao P, Chen G, Shang-Guan H, Lin Q, Wang X, Zheng S Medicine (Baltimore). 2018; 96(51):e8894.
PMID: 29390424 PMC: 5758126. DOI: 10.1097/MD.0000000000008894.