Recent Advances in Small-animal Cardiovascular Imaging

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 2009 Apr 18

PMID 19372476

Citations 18

Authors

Benjamin M W Tsui

Dara L Kraitchman

Affiliations

Soon will be listed here.

Abstract

Because of the development of gene knockout and transgenic technologies, small animals, such as mice and rats, have become the most widely used animals for cardiovascular imaging studies. Imaging can provide a method to serially evaluate the effect of a particular genetic mutation or pharmacologic therapy (1). In addition, imaging can be used as a noninvasive screening tool for particular cardiovascular phenotypes. Outcome measures of therapeutic efficacy, such as ejection fraction, left ventricular mass, and ventricular volume, can be determined noninvasively as well. Furthermore, small-animal imaging can be used to develop and test new molecular imaging probes (2,3). However, the small size of the heart and rapid heart rate of murine models create special challenges for cardiovascular imaging.

Citing Articles

Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects.

DElia A, Schiavi S, Soluri A, Massari R, Soluri A, Trezza V Front Behav Neurosci. 2020; 14:596509.

PMID: 33362486 PMC: 7759612. DOI: 10.3389/fnbeh.2020.596509.

Studying the cardiovascular system of a marine crustacean with magnetic resonance imaging at 9.4 T.

Maus B, Portner H, Bock C MAGMA. 2019; 32(5):567-579.

PMID: 31124010 DOI: 10.1007/s10334-019-00752-4.

Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Lerman L, Kurtz T, Touyz R, Ellison D, Chade A, Crowley S Hypertension. 2019; 73(6):e87-e120.

PMID: 30866654 PMC: 6740245. DOI: 10.1161/HYP.0000000000000090.

3D + time blood flow mapping using SPIM-microPIV in the developing zebrafish heart.

Zickus V, Taylor J Biomed Opt Express. 2018; 9(5):2418-2435.

PMID: 29760998 PMC: 5946799. DOI: 10.1364/BOE.9.002418.

9.4 T small animal MRI using clinical components for direct translational studies.

Felder J, Celik A, Choi C, Schwan S, Jon Shah N J Transl Med. 2017; 15(1):264.

PMID: 29282070 PMC: 5745792. DOI: 10.1186/s12967-017-1373-7.

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