Investigation of Temperature-dependent Viscoelastic Properties of Thermal Lesions in Ex Vivo Animal Liver Tissue

Overview

Journal J Biomech

Specialty Physiology

Date 2009 Apr 14

PMID 19362313

Citations 15

Authors

Miklos Z Kiss

Matthew J Daniels

Tomy Varghese

Affiliations

Soon will be listed here.

Abstract

The viscoelastic characteristics of thermal lesions in ex vivo animal liver are investigated in this paper. Characterization of the moduli of thermal lesions prepared at several temperatures will provide additional information for the elastographic monitoring of radio frequency ablation of hepatic tumors. In this study, the frequency-dependent complex modulus of thermal lesions prepared at temperatures ranging from 60 to 90 degrees C over a frequency range from 0.1 to 50Hz are presented. Lesions were prepared using either radio frequency ablation or double immersion boiling. It was found that both the magnitude and phase of the modulus increase with frequency, a behavior that has been noted in the literature. A new result reported shows that the modulus dependence on temperature reveals a local maximum around 70-75 degrees C corresponding to the temperature at which tissue has released most of its water content. The modulus values at temperatures higher than 70 degrees C continued to increase, but the extent of increase depend on animal species and other factors.

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References

Geerligs M, Peters G, Ackermans P, Oomens C, Baaijens F . Linear viscoelastic behavior of subcutaneous adipose tissue. Biorheology. 2008; 45(6):677-88. View

Moffitt T, Baker D, Kirkpatrick S, Prahl S . Mechanical properties of coagulated albumin and failure mechanisms of liver repaired with the use of an argon-beam coagulator with albumin. J Biomed Mater Res. 2002; 63(6):722-8. DOI: 10.1002/jbm.10389. View

Stafford R, Kallel F, Price R, Cromeens D, Krouskop T, Hazle J . Elastographic imaging of thermal lesions in soft tissue: a preliminary study in vitro. Ultrasound Med Biol. 1999; 24(9):1449-58. DOI: 10.1016/s0301-5629(98)00099-4. View

Suki B, Barabasi A, Lutchen K . Lung tissue viscoelasticity: a mathematical framework and its molecular basis. J Appl Physiol (1985). 1994; 76(6):2749-59. DOI: 10.1152/jappl.1994.76.6.2749. View

Garra B, Cespedes E, Ophir J, Spratt S, Zuurbier R, Magnant C . Elastography of breast lesions: initial clinical results. Radiology. 1997; 202(1):79-86. DOI: 10.1148/radiology.202.1.8988195. View

Samali A, Holmberg C, Sistonen L, Orrenius S . Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins. FEBS Lett. 1999; 461(3):306-10. DOI: 10.1016/s0014-5793(99)01486-6. View

Kiss M, Varghese T, Hall T . Viscoelastic characterization of in vitro canine tissue. Phys Med Biol. 2004; 49(18):4207-18. PMC: 2409005. DOI: 10.1088/0031-9155/49/18/002. View

Chin L, Sherar M . Changes in dielectric properties of ex vivo bovine liver at 915 MHz during heating. Phys Med Biol. 2001; 46(1):197-211. DOI: 10.1088/0031-9155/46/1/314. View

Sacks M, Sun W . Multiaxial mechanical behavior of biological materials. Annu Rev Biomed Eng. 2003; 5:251-84. DOI: 10.1146/annurev.bioeng.5.011303.120714. View

10.

Hoyt K, Castaneda B, Zhang M, Nigwekar P, di SantAgnese P, Joseph J . Tissue elasticity properties as biomarkers for prostate cancer. Cancer Biomark. 2008; 4(4-5):213-25. PMC: 3144495. DOI: 10.3233/cbm-2008-44-505. View

11.

Soergel F, Meyer C, Eckert G, Abele B, Pechhold W . Spectral analysis of viscoelasticity of the human lens. J Refract Surg. 1999; 15(6):714-6. DOI: 10.3928/1081-597X-19991101-22. View

12.

Gertner M, Wilson B, Sherar M . Ultrasound properties of liver tissue during heating. Ultrasound Med Biol. 1997; 23(9):1395-403. DOI: 10.1016/s0301-5629(97)00150-6. View

13.

Techavipoo U, Varghese T, Chen Q, Stiles T, Zagzebski J, Frank G . Temperature dependence of ultrasonic propagation speed and attenuation in excised canine liver tissue measured using transmitted and reflected pulses. J Acoust Soc Am. 2004; 115(6):2859-65. DOI: 10.1121/1.1738453. View

14.

Varghese T, Zagzebski J, Lee Jr F . Elastographic imaging of thermal lesions in the liver in vivo following radiofrequency ablation: preliminary results. Ultrasound Med Biol. 2002; 28(11-12):1467-73. DOI: 10.1016/s0301-5629(02)00656-7. View

15.

Privalov P . Stability of proteins. Proteins which do not present a single cooperative system. Adv Protein Chem. 1982; 35:1-104. View

16.

Sridhar M, Liu J, Insana M . Viscoelasticity imaging using ultrasound: parameters and error analysis. Phys Med Biol. 2007; 52(9):2425-43. PMC: 2713776. DOI: 10.1088/0031-9155/52/9/007. View

17.

Sinkus R, Siegmann K, Xydeas T, Tanter M, Claussen C, Fink M . MR elastography of breast lesions: understanding the solid/liquid duality can improve the specificity of contrast-enhanced MR mammography. Magn Reson Med. 2007; 58(6):1135-44. DOI: 10.1002/mrm.21404. View

18.

Chen S, Humphrey J . Heat-induced changes in the mechanics of a collagenous tissue: pseudoelastic behavior at 37 degrees C. J Biomech. 1998; 31(3):211-6. DOI: 10.1016/s0021-9290(97)00121-8. View

19.

Yeh W, Li P, Jeng Y, Hsu H, Kuo P, Li M . Elastic modulus measurements of human liver and correlation with pathology. Ultrasound Med Biol. 2002; 28(4):467-74. DOI: 10.1016/s0301-5629(02)00489-1. View

20.

Samani A, Bishop J, Luginbuhl C, Plewes D . Measuring the elastic modulus of ex vivo small tissue samples. Phys Med Biol. 2003; 48(14):2183-98. DOI: 10.1088/0031-9155/48/14/310. View