Magnetic Resonance Imaging of Boiling Induced by High Intensity Focused Ultrasound

Overview

Journal J Acoust Soc Am

Publisher American Institute of Physics

Specialty Otorhinolaryngology

Date 2009 Apr 10

PMID 19354416

Citations 26

Authors

Tatiana D Khokhlova

Michael S Canney

Donghoon Lee

Kenneth I Marro

Lawrence A Crum

Vera A Khokhlova

Michael R Bailey

Affiliations

Soon will be listed here.

Abstract

Both mechanically induced acoustic cavitation and thermally induced boiling can occur during high intensity focused ultrasound (HIFU) medical therapy. The goal was to monitor the temperature as boiling was approached using magnetic resonance imaging (MRI). Tissue phantoms were heated for 20 s in a 4.7-T magnet using a 2-MHz HIFU source with an aperture and radius of curvature of 44 mm. The peak focal pressure was 27.5 MPa with corresponding beam width of 0.5 mm. The temperature measured in a single MRI voxel by water proton resonance frequency shift attained a maximum value of only 73 degrees C after 7 s of continuous HIFU exposure when boiling started. Boiling was detected by visual observation, by appearance on the MR images, and by a marked change in the HIFU source power. Nonlinear modeling of the acoustic field combined with a heat transfer equation predicted 100 degrees C after 7 s of exposure. Averaging of the calculated temperature field over the volume of the MRI voxel (0.3 x 0.5 x 2 mm(3)) yielded a maximum of 73 degrees C that agreed with the MR thermometry measurement. These results have implications for the use of MRI-determined temperature values to guide treatments with clinical HIFU systems.

Citing Articles

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Lari S, Kohandel M, Kwon H Sci Rep. 2024; 14(1):20042.

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Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.

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Weakly nonlinear focused ultrasound in viscoelastic media containing multiple bubbles.

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Quantitative Assessment of Boiling Histotripsy Progression Based on Color Doppler Measurements.

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