Mitochondrial Hexokinase and Cardioprotection of the Intact Heart

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 2009 Apr 7

PMID 19347573

Citations 19

Authors

C J Zuurbier

K M A Smeele

O Eerbeek

Affiliations

Soon will be listed here.

Abstract

The interaction of hexokinase with mitochondria has emerged as a powerful mechanism in protecting many cell types against cell death. However, the role of mitochondrial hexokinase (mitoHK) in cardiac ischemia-reperfusion injury has as of yet received little attention. In this review we examine whether increased binding of hexokinase to the mitochondrion is also an integral component of cardioprotective signalling. We discuss observations in cardiac mitochondrial activation that directed us to the hypothesis of hexokinase cellular redistribution with reversible, cardioprotective ischemia, summarize the data showing that many cardioprotective interventions, such as ischemic preconditioning, insulin, morphine and volatile anesthetics, increase mitochondrial hexokinase binding within the intact heart, and discuss similarities between mitochondrial hexokinase association and ischemic preconditioning. Although most data indicate that mitochondrial hexokinase may indeed be an integral part of cardioprotection, a definitive proof for a causal relation between the amount of mitoHK and cardiac ischemia-reperfusion injury in the intact heart is eagerly awaited. When such relationship is indeed observed, the association of hexokinase with mitochondria will offer an opportunity to develop new therapies to combat ischemic cardiac diseases.

Citing Articles

Cardiac metabolism as a driver and therapeutic target of myocardial infarction.

Zuurbier C, Bertrand L, Beauloye C, Andreadou I, Ruiz-Meana M, Jespersen N J Cell Mol Med. 2020; 24(11):5937-5954.

PMID: 32384583 PMC: 7294140. DOI: 10.1111/jcmm.15180.

Glycogen synthase kinase-3β opens mitochondrial permeability transition pore through mitochondrial hexokinase II dissociation.

Tanaka T, Saotome M, Katoh H, Satoh T, Hasan P, Ohtani H J Physiol Sci. 2018; 68(6):865-871.

PMID: 29671257 PMC: 10717190. DOI: 10.1007/s12576-018-0611-y.

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis.

Zhou H, Zhang Y, Hu S, Shi C, Zhu P, Ma Q J Pineal Res. 2017; 63(1).

PMID: 28398674 PMC: 5518188. DOI: 10.1111/jpi.12413.

Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult.

Kolar D, Gresikova M, Waskova-Arnostova P, Elsnicova B, Kohutova J, Hornikova D Mol Cell Biochem. 2017; 432(1-2):99-108.

PMID: 28290047 DOI: 10.1007/s11010-017-3001-5.

Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening.

Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P J Am Heart Assoc. 2017; 6(3).

PMID: 28288978 PMC: 5524036. DOI: 10.1161/JAHA.116.005328.

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