Transcriptional Control of Brown Adipocyte Development and Physiological Function--of Mice and Men

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2009 Apr 3

PMID 19339685

Citations 139

Authors

Patrick Seale

Shingo Kajimura

Bruce M Spiegelman

Affiliations

Soon will be listed here.

Abstract

The last several years have seen an explosion of information relating to the transcriptional control of brown fat cell development. At the same time, new data have emerged that clearly demonstrate that adult humans do indeed have substantial amounts of functioning brown adipose tissue (BAT). Together, these advances are stimulating a reassessment of the role of brown adipose tissue in human physiology and pathophysiology. These data have also opened up exciting new opportunities for the development of entirely novel classes of therapeutics for metabolic diseases like obesity and type 2 diabetes.

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