VEGF and Endothelial Guidance in Angiogenic Sprouting

Overview

Journal Organogenesis

Specialties Anatomy & Histology
Biology
Biotechnology

Date 2009 Apr 2

PMID 19337404

Citations 129

Authors

Holger Gerhardt

Affiliations

Soon will be listed here.

Abstract

The cellular actions of VEGF need to be coordinated to guide vascular patterning during sprouting angiogenesis. Individual endothelial tip cells lead and guide the blood vessel sprout, while neighbouring stalk cells proliferate and form the vascular lumen. Recent studies illustrate how endothelial DLL4/NOTCH signalling, stimulated by VEGF, regulates the sprouting response by limiting tip cell formation in the stalk. The spatial distribution of VEGF, in turn, regulates the shape of the ensuing sprout by directing tip cell migration and determining stalk cell proliferation.

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