The Role of Indoor Allergens in the Development of Asthma

Overview

Journal Curr Opin Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2009 Mar 28

PMID 19326507

Citations 53

Authors

Jonathan M Gaffin

Wanda Phipatanakul

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Asthma prevalence has markedly increased over the past 30 years. Although atopy and exposure to environmental allergens are known to exacerbate asthma, recent literature supports a causal role of indoor allergens in disease development.

Recent Findings: High-risk birth cohorts continue to point to atopy as the main risk factor for developing asthma. Exposure to perennial allergens has also been linked to the development of asthma, though with less consistency. Intervention at the level of allergen exposure and allergic immune response is promising.

Summary: The current model of atopic asthma, the predominant phenotype, incorporates genetic and environmental factors in the development of disease. Although genetic factors are less malleable, the environmental component lends itself to analysis and modification.For many, the development of asthma starts with allergen exposure leading to atopic sensitization and subsequent disease. Several studies support the progression from exposure to sensitization with the potential of extremely high levels of exposure leading to tolerance. Likewise, the progression from atopy to asthma is well documented,especially in genetically predisposed children. Recent intervention trials confirm these findings and begin to show promise for the prevention of asthma by interrupting the allergen exposure==>allergen sensitization==>atopic asthma pathway.

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References

Klepeis N, Nelson W, Ott W, Robinson J, Tsang A, Switzer P . The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol. 2001; 11(3):231-52. DOI: 10.1038/sj.jea.7500165. View

van Strien R, Koopman L, Kerkhof M, Oldenwening M, de Jongste J, Gerritsen J . Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy. 2003; 33(4):490-5. DOI: 10.1046/j.1365-2222.2003.01626.x. View

Chan-Yeung M, Ferguson A, Watson W, Dimich-Ward H, Rousseau R, Lilley M . The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol. 2005; 116(1):49-55. DOI: 10.1016/j.jaci.2005.03.029. View

Marks G, Mihrshahi S, Kemp A, Tovey E, Webb K, Almqvist C . Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol. 2006; 118(1):53-61. DOI: 10.1016/j.jaci.2006.04.004. View

Munir A, Kjellman N, Bjorksten B . Exposure to indoor allergens in early infancy and sensitization. J Allergy Clin Immunol. 1997; 100(2):177-81. DOI: 10.1016/s0091-6749(97)70221-5. View

Niggemann B, Jacobsen L, Dreborg S, Ferdousi H, Halken S, Host A . Five-year follow-up on the PAT study: specific immunotherapy and long-term prevention of asthma in children. Allergy. 2006; 61(7):855-9. DOI: 10.1111/j.1398-9995.2006.01068.x. View

Moorman J, Anne Rudd R, Johnson C, King M, Minor P, Bailey C . National surveillance for asthma--United States, 1980-2004. MMWR Surveill Summ. 2007; 56(8):1-54. View

Henderson J, Granell R, Heron J, Sherriff A, Simpson A, Woodcock A . Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax. 2008; 63(11):974-80. PMC: 2582336. DOI: 10.1136/thx.2007.093187. View

Kusel M, de Klerk N, Kebadze T, Vohma V, Holt P, Johnston S . Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol. 2007; 119(5):1105-10. PMC: 7125611. DOI: 10.1016/j.jaci.2006.12.669. View

10.

Oddy W, de Klerk N, Sly P, Holt P . The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J. 2002; 19(5):899-905. DOI: 10.1183/09031936.02.00103602. View

11.

Platts-Mills T, Leung D, Schatz M . The role of allergens in asthma. Am Fam Physician. 2007; 76(5):675-80. View

12.

Litonjua A, Carey V, Burge H, Weiss S, Gold D . Exposure to cockroach allergen in the home is associated with incident doctor-diagnosed asthma and recurrent wheezing. J Allergy Clin Immunol. 2001; 107(1):41-7. DOI: 10.1067/mai.2001.111143. View

13.

Platts-Mills T, Vaughan J, Blumenthal K, Pollart Squillace S, Sporik R . Serum IgG and IgG4 antibodies to Fel d 1 among children exposed to 20 microg Fel d 1 at home: relevance of a nonallergic modified Th2 response. Int Arch Allergy Immunol. 2001; 124(1-3):126-9. DOI: 10.1159/000053689. View

14.

Cantani A, Ciaschi V . Epidemiology of alternaria alternata allergy: a prospective study in 6840 Italian asthmatic children. Eur Rev Med Pharmacol Sci. 2005; 8(6):289-94. View

15.

Illi S, von Mutius E, Lau S, Nickel R, Niggemann B, Sommerfeld C . The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol. 2001; 108(5):709-14. DOI: 10.1067/mai.2001.118786. View

16.

Xuan W, Marks G, Toelle B, Belousova E, Peat J, Berry G . Risk factors for onset and remission of atopy, wheeze, and airway hyperresponsiveness. Thorax. 2002; 57(2):104-9. PMC: 1746247. DOI: 10.1136/thorax.57.2.104. View

17.

Wickman M, Korsgaard J . Transient sensitization to house-dust mites: a study on the influence of mite exposure and sex. Allergy. 1996; 51(7):511-3. DOI: 10.1111/j.1398-9995.1996.tb04658.x. View

18.

Marogna M, Tomassetti D, Bernasconi A, Colombo F, Massolo A, Businco A . Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study. Ann Allergy Asthma Immunol. 2008; 101(2):206-11. DOI: 10.1016/s1081-1206(10)60211-6. View

19.

Lowe L, Woodcock A, Murray C, Morris J, Simpson A, Custovic A . Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2004; 158(10):996-1001. DOI: 10.1001/archpedi.158.10.996. View

20.

Polk S, Sunyer J, Munoz-Ortiz L, Barnes M, Torrent M, Figueroa C . A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing. Am J Respir Crit Care Med. 2004; 170(3):273-8. DOI: 10.1164/rccm.200310-1348OC. View