Depiction of Major Mite Allergens in Severe Allergic Rhinitis with High Mite Perennial Exposure

Overview

Journal Turk Arch Otorhinolaryngol

Publisher Galenos Publishing House

Specialty Otorhinolaryngology

Date 2020 Nov 4

PMID 33145499

Citations 1

Authors

Ruperto Gonzalez-Perez

Paloma Poza-Guedes

Fernando Pineda

Miriam Castillo

Affiliations

Soon will be listed here.

Abstract

Objective: Airway diseases, including allergic rhinitis, are prompted by specific IgE antibodies against airborne allergens and notably those derived from mites. The presented study focused on the specific IgE immediate response to () mite major allergens and the corresponding pertinence of molecular diagnosis in patients bothered with severe persistent rhinitis.

Methods: Individuals exhibiting confirmed sensitization to along with a clinical diagnosis of coexisting severe allergic rhinitis were included in the study. In vivo investigations encompassed intradermal testing with a battery of standardized allergenic extracts, concurrent with specific IgE to the crude extract of , and associated individual molecular allergens were assessed.

Results: Fifty-five out of 59 subjects showed serodominant IgE responses to the major allergens Der p 1, Der p 2 and Der p 23. Both Der p 2 and Der p 23 reached a prevalence above 80%, while group 10 allergen tropomyosin was scarcely depicted (<10%) and exclusively present in younger individuals.

Conclusion: The proposed component-resolved diagnosis panel accurately recognized 93.22% of allergic patients. The raised seroprevalence of IgE response to Der p 23 also confirmed this constituent as a major allergen in severe allergic rhinitis. A molecular approach appears to be essential to frame a more precise diagnosis and eventually a personalized immunotherapy regarding this allergic condition.

Citing Articles

The Asthma Risk Is Increased in Children with Severe Allergic Rhinitis.

Kaya Akca U, Maslak I, Uygun D, Bingol A Turk Arch Pediatr. 2022; 57(4):391-397.

PMID: 35822470 PMC: 9476271. DOI: 10.5152/TurkArchPediatr.2022.21269.

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