Adult Deafness Induces Somatosensory Conversion of Ferret Auditory Cortex

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 Mar 25

PMID 19307553

Citations 47

Authors

Brian L Allman

Leslie P Keniston

M Alex Meredith

Affiliations

Soon will be listed here.

Abstract

In response to early or developmental lesions, responsiveness of sensory cortex can be converted from the deprived modality to that of the remaining sensory systems. However, little is known about capacity of the adult cortex for cross-modal reorganization. The present study examined the auditory cortices of animals deafened as adults, and observed an extensive somatosensory conversion within as little as 16 days after deafening. These results demonstrate that cortical cross-modal reorganization can occur after the period of sensory system maturation.

Citing Articles

Visual Reliance in Severe Hearing Loss: Visual Evoked Potentials (VEPs) Study.

Gabr T, Hashem A, Ahmed S, Zeinhom M Audiol Res. 2025; 15(1.

PMID: 39846556 PMC: 11755637. DOI: 10.3390/audiolres15010003.

Neuroplastic changes in functional wiring in sensory cortices of the congenitally deaf: A network analysis.

Ruttorf M, Tal Z, Amaral L, Fang F, Bi Y, Almeida J Hum Brain Mapp. 2023; 44(18):6523-6536.

PMID: 37956260 PMC: 10681644. DOI: 10.1002/hbm.26530.

Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex.

Calhoun G, Chen C, Kanold P Proc Natl Acad Sci U S A. 2023; 120(30):e2219340120.

PMID: 37459544 PMC: 10372568. DOI: 10.1073/pnas.2219340120.

Crossmodal plasticity in hearing loss.

Kral A, Sharma A Trends Neurosci. 2023; 46(5):377-393.

PMID: 36990952 PMC: 10121905. DOI: 10.1016/j.tins.2023.02.004.

Somatosensory processing in deaf and deafblind individuals: How does the brain adapt as a function of sensory and linguistic experience? A critical review.

Villwock A, Grin K Front Psychol. 2022; 13:938842.

PMID: 36324786 PMC: 9618853. DOI: 10.3389/fpsyg.2022.938842.

References

Proops D, Donaldson I, COOPER H, Thomas J, Burrell S, Stoddart R . Outcomes from adult implantation, the first 100 patients. J Laryngol Otol Suppl. 2000; 24:5-13. View

Buonomano D, Merzenich M . Cortical plasticity: from synapses to maps. Annu Rev Neurosci. 1998; 21:149-86. DOI: 10.1146/annurev.neuro.21.1.149. View

Kaas J, Krubitzer L, Chino Y, Langston A, POLLEY E, Blair N . Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina. Science. 1990; 248(4952):229-31. DOI: 10.1126/science.2326637. View

Rebillard G, Carlier E, Rebillard M, Pujol R . Enhancement of visual responses on the primary auditory cortex of the cat after an early destruction of cochlear receptors. Brain Res. 1977; 129(1):162-4. DOI: 10.1016/0006-8993(77)90980-5. View

Mrsic-Flogel T, Versnel H, King A . Development of contralateral and ipsilateral frequency representations in ferret primary auditory cortex. Eur J Neurosci. 2006; 23(3):780-92. DOI: 10.1111/j.1460-9568.2006.04609.x. View

Yaka R, Yinon U, Rosner M, Wollberg Z . Pathological and experimentally induced blindness induces auditory activity in the cat primary visual cortex. Exp Brain Res. 2000; 131(1):144-8. DOI: 10.1007/s002219900295. View

Allman B, Meredith M . Multisensory processing in "unimodal" neurons: cross-modal subthreshold auditory effects in cat extrastriate visual cortex. J Neurophysiol. 2007; 98(1):545-9. DOI: 10.1152/jn.00173.2007. View

Agrawal Y, Platz E, Niparko J . Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, 1999-2004. Arch Intern Med. 2008; 168(14):1522-30. DOI: 10.1001/archinte.168.14.1522. View

Dehmel S, Cui Y, Shore S . Cross-modal interactions of auditory and somatic inputs in the brainstem and midbrain and their imbalance in tinnitus and deafness. Am J Audiol. 2008; 17(2):S193-209. PMC: 2760229. DOI: 10.1044/1059-0889(2008/07-0045). View

10.

Kanold P, Young E . Proprioceptive information from the pinna provides somatosensory input to cat dorsal cochlear nucleus. J Neurosci. 2001; 21(19):7848-58. PMC: 6762891. View

11.

Manger P, Masiello I, Innocenti G . Areal organization of the posterior parietal cortex of the ferret (Mustela putorius). Cereb Cortex. 2002; 12(12):1280-97. DOI: 10.1093/cercor/12.12.1280. View

12.

Hunt D, Yamoah E, Krubitzer L . Multisensory plasticity in congenitally deaf mice: how are cortical areas functionally specified?. Neuroscience. 2006; 139(4):1507-24. DOI: 10.1016/j.neuroscience.2006.01.023. View

13.

Clemo H, Sharma G, Allman B, Meredith M . Auditory projections to extrastriate visual cortex: connectional basis for multisensory processing in 'unimodal' visual neurons. Exp Brain Res. 2008; 191(1):37-47. PMC: 2827203. DOI: 10.1007/s00221-008-1493-7. View

14.

Moore C, Vollmer M, Leake P, Snyder R, Rebscher S . The effects of chronic intracochlear electrical stimulation on inferior colliculus spatial representation in adult deafened cats. Hear Res. 2002; 164(1-2):82-96. DOI: 10.1016/s0378-5955(01)00415-4. View

15.

Xu S, Shepherd R, Chen Y, Clark G . Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid. Hear Res. 1993; 70(2):205-15. DOI: 10.1016/0378-5955(93)90159-x. View

16.

Kral A, Schroder J, Klinke R, Engel A . Absence of cross-modal reorganization in the primary auditory cortex of congenitally deaf cats. Exp Brain Res. 2003; 153(4):605-13. DOI: 10.1007/s00221-003-1609-z. View

17.

Yaka R, Yinon U, Wollberg Z . Auditory activation of cortical visual areas in cats after early visual deprivation. Eur J Neurosci. 1999; 11(4):1301-12. DOI: 10.1046/j.1460-9568.1999.00536.x. View

18.

Xerri C . Imprinting of idiosyncratic experience in cortical sensory maps: neural substrates of representational remodeling and correlative perceptual changes. Behav Brain Res. 2008; 192(1):26-41. DOI: 10.1016/j.bbr.2008.02.038. View

19.

Auer Jr E, Bernstein L, Sungkarat W, Singh M . Vibrotactile activation of the auditory cortices in deaf versus hearing adults. Neuroreport. 2007; 18(7):645-8. PMC: 1934619. DOI: 10.1097/WNR.0b013e3280d943b9. View

20.

Rauschecker J, Korte M . Auditory compensation for early blindness in cat cerebral cortex. J Neurosci. 1993; 13(10):4538-48. PMC: 6576362. View