Reduced Expression of Alpha-1,2-mannosidase I Extends Lifespan in Drosophila Melanogaster and Caenorhabditis Elegans

Overview

Journal Aging Cell

Specialties Cell Biology
Geriatrics

Date 2009 Mar 24

PMID 19302370

Citations 20

Authors

Ya-Lin Liu

Wan-Chih Lu

Theodore J Brummel

Chiou-Hwa Yuh

Pei-Ting Lin

Tzu-Yu Kao

Fang-Yi Li

Pin-Chao Liao

Seymour Benzer

Horng-Dar Wang

Affiliations

Soon will be listed here.

Abstract

Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancement is also observed when mas1 expression is reduced via RNA interference in both Drosophila melanogaster and Caenorhabditis elegans. The screen also identified Edem1 (Edm1), a gene downstream of mas1, as a modulator of lifespan. As double mutants for both mas1 and Edm1 showed no additional longevity enhancement, it appeared that both mutations function within a common pathway to extend lifespan. Molecular analysis of these mutants revealed that the expression of BiP, a putative biomarker of dietary restriction (DR), is down-regulated in response to reductions in mas1 expression. These findings suggested that mutations in mas1 may extend longevity by modulating DR.

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