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High Sensitivity and Specificity of Acid-fast Microscopy for Diagnosis of Pulmonary Tuberculosis in an African Population with a High Prevalence of Human Immunodeficiency Virus

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 2009 Mar 20
PMID 19297594
Citations 14
Authors
Yvonne R Shea
J Lucian Davis
Laurence Huang
Joseph A Kovacs
Henry Masur
Francis Mulindwa
Sally Opus
Yuenwah Chow
Patrick R Murray
Affiliations
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Abstract

Laboratories in low-income countries report that acid-fast microscopy is insensitive and nonspecific. We demonstrate that for a Ugandan population with high prevalences of tuberculosis and human immunodeficiency virus infection, acid-fast microscopy is highly sensitive (93.1%) and specific (100%) when performed by trained technologists in a carefully controlled manner using established techniques.

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