A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2009 Mar 17

PMID 19287003

Citations 31

Authors

Danaya Pakotiprapha

Yi Liu

Gregory L Verdine

David Jeruzalmi

Affiliations

Soon will be listed here.

Abstract

Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA.UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.

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