Animal Models of Suicide-trait-related Behaviors

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2009 Mar 10

PMID 19269045

Citations 20

Authors

Oz Malkesman

Daniel S Pine

Tyson Tragon

Daniel R Austin

Ioline D Henter

Guang Chen

Husseini K Manji

Affiliations

Soon will be listed here.

Abstract

Although antidepressants are moderately effective in treating major depressive disorder (MDD), concerns have arisen that selective serotonin-reuptake inhibitors (SSRIs) are associated with suicidal thinking and behavior, especially in children, adolescents and young adults. Almost no experimental research in model systems has considered the mechanisms by which SSRIs might be associated with this potential side effect in some susceptible individuals. Suicide is a complex behavior and impossible to fully reproduce in an animal model. However, by investigating traits that show strong cross-species parallels in addition to associations with suicide in humans, animal models might elucidate the mechanisms by which SSRIs are associated with suicidal thinking and behavior. Traits linked with suicide in humans that can be successfully modeled in rodents include aggression, impulsivity, irritability and hopelessness/helplessness. Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population.

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