Remittance at a Single Wavelength of 390 Nm to Quantify Epidermal Melanin Concentration

Overview

Journal J Biomed Opt

Specialties Biomedical Engineering
Ophthalmology

Date 2009 Mar 5

PMID 19256693

Citations 5

Authors

Wim Verkruysse

Lars O Svaasand

Walfre Franco

J Stuart Nelson

Affiliations

Soon will be listed here.

Abstract

Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390 nm as an alternative optical method to determine EMC and IMSRE. Remittance spectra (360 to 740 nm), melanin index (MI) measurements and the transient radiometric temperature increase, DeltaT(t), upon skin irradiation with an Alexandrite laser (755 nm, 3-ms pulse duration, 6 Jcm(2)) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390 nm appears to provide better estimates for EMC and IMSRE than MI.

Citing Articles

Melanometry for objective evaluation of skin pigmentation in pulse oximetry studies.

Vasudevan S, Vogt W, Weininger S, Pfefer T Commun Med (Lond). 2024; 4(1):138.

PMID: 38992188 PMC: 11239860. DOI: 10.1038/s43856-024-00550-7.

Melanins as Sustainable Resources for Advanced Biotechnological Applications.

Galeb H, Wilkinson E, Stowell A, Lin H, Murphy S, Martin-Hirsch P Glob Chall. 2021; 5(2):2000102.

PMID: 33552556 PMC: 7857133. DOI: 10.1002/gch2.202000102.

Multidiameter single-fiber reflectance spectroscopy of heavily pigmented skin: modeling the inhomogeneous distribution of melanin.

Zhang X, van der Zee P, Atzeni I, Faber D, van Leeuwen T, Sterenborg H J Biomed Opt. 2019; 24(12):1-11.

PMID: 31820596 PMC: 7006040. DOI: 10.1117/1.JBO.24.12.127001.

A review of melanin sensor devices.

Kanellis V Biophys Rev. 2019; 11(6):843-849.

PMID: 31396804 PMC: 6874939. DOI: 10.1007/s12551-019-00581-8.

Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo.

Zhang C, Maslov K, Wang L Opt Lett. 2010; 35(19):3195-7.

PMID: 20890331 PMC: 2952183. DOI: 10.1364/OL.35.003195.

References

Dolotov L, Sinichkin Y, Tuchin V, Utz S, Altshuler G, Yaroslavsky I . Design and evaluation of a novel portable erythema-melanin-meter. Lasers Surg Med. 2004; 34(2):127-35. DOI: 10.1002/lsm.10233. View

Kollias N, Stamatas G . Optical non-invasive approaches to diagnosis of skin diseases. J Investig Dermatol Symp Proc. 2003; 7(1):64-75. DOI: 10.1046/j.1523-1747.2002.19635.x. View

Andersen P, Bjerring P . Noninvasive computerized analysis of skin chromophores in vivo by reflectance spectroscopy. Photodermatol Photoimmunol Photomed. 1990; 7(6):249-57. View

Alaluf S, Atkins D, Barrett K, Blount M, Carter N, Heath A . The impact of epidermal melanin on objective measurements of human skin colour. Pigment Cell Res. 2002; 15(2):119-26. DOI: 10.1034/j.1600-0749.2002.1o072.x. View

Dwyer T, Blizzard L, Ashbolt R, Plumb J, Berwick M, Stankovich J . Cutaneous melanin density of Caucasians measured by spectrophotometry and risk of malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin. Am J Epidemiol. 2002; 155(7):614-21. DOI: 10.1093/aje/155.7.614. View

Takiwaki H, Shirai S, Kanno Y, Watanabe Y, Arase S . Quantification of erythema and pigmentation using a videomicroscope and a computer. Br J Dermatol. 1994; 131(1):85-92. DOI: 10.1111/j.1365-2133.1994.tb08462.x. View

Andersen P, Bjerring P . Spectral reflectance of human skin in vivo. Photodermatol Photoimmunol Photomed. 1990; 7(1):5-12. View

Dwyer T, Muller H, Blizzard L, Ashbolt R, Phillips G . The use of spectrophotometry to estimate melanin density in Caucasians. Cancer Epidemiol Biomarkers Prev. 1998; 7(3):203-6. View

Dawson J, Barker D, Ellis D, Grassam E, Cotterill J, Fisher G . A theoretical and experimental study of light absorption and scattering by in vivo skin. Phys Med Biol. 1980; 25(4):695-709. DOI: 10.1088/0031-9155/25/4/008. View

10.

Moncrieff M, Cotton S, Claridge E, Hall P . Spectrophotometric intracutaneous analysis: a new technique for imaging pigmented skin lesions. Br J Dermatol. 2002; 146(3):448-57. DOI: 10.1046/j.1365-2133.2002.04569.x. View

11.

Stamatas G, Zmudzka B, Kollias N, Beer J . Non-invasive measurements of skin pigmentation in situ. Pigment Cell Res. 2004; 17(6):618-26. DOI: 10.1111/j.1600-0749.2004.00204.x. View

12.

Verkruysse W, Jia W, Franco W, Milner T, Nelson J . Infrared measurement of human skin temperature to predict the individual maximum safe radiant exposure (IMSRE). Lasers Surg Med. 2007; 39(10):757-66. DOI: 10.1002/lsm.20581. View

13.

Kollias N, Baqer A . Spectroscopic characteristics of human melanin in vivo. J Invest Dermatol. 1985; 85(1):38-42. DOI: 10.1111/1523-1747.ep12275011. View

14.

Kollias N, Baqer A . On the assessment of melanin in human skin in vivo. Photochem Photobiol. 1986; 43(1):49-54. DOI: 10.1111/j.1751-1097.1986.tb05590.x. View

15.

Matts P, Dykes P, Marks R . The distribution of melanin in skin determined in vivo. Br J Dermatol. 2007; 156(4):620-8. DOI: 10.1111/j.1365-2133.2006.07706.x. View

16.

Wolbarsht M, Walsh A, George G . Melanin, a unique biological absorber. Appl Opt. 2010; 20(13):2184-6. DOI: 10.1364/AO.20.002184. View