Cellular and Molecular Mechanisms of Memory T-cell Survival

Overview

Journal Expert Rev Vaccines

Date 2009 Mar 3

PMID 19249972

Citations 19

Authors

Andre Tanel

Simone G Fonseca

Bader Yassine-Diab

Rebeka Bordi

Joumana Zeidan

Yu Shi

Clarisse Benne

Rafick-Pierre Sekaly

Affiliations

Soon will be listed here.

Abstract

Long-term maintenance of the memory T-cell response is the hallmark of immune protection and, hence, constitutes one of the most important objectives of vaccine-development strategies. Persistent memory T cells, developed after vaccination or microbial infections, ensure the generation of an antimicrobial response upon re-exposure to the pathogen through rapid clonal proliferation and activation of effector functions. However, in the context of many pathogen infections, these memory T cells fail to persist and die. In this review, we will highlight recent exciting findings in studies of memory T cells, their generation, their lineage relationships and their survival pathways; indeed, survival of memory T cells and maintenance of their functionality are key features of the immune response in its quest to control disease progression and in the development of vaccines to persistent microbial infections.

Citing Articles

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