Adherence to Antimalarial Drug Therapy Among Vivax Malaria Patients in Northern Thailand

Overview

Journal J Health Popul Nutr

Publisher Biomed Central

Specialties Nutritional Sciences
Public Health

Date 2009 Mar 3

PMID 19248643

Citations 50

Authors

Nardlada Khantikul

Piyarat Butraporn

Han S Kim

Somjai Leemingsawat

M A Sandra B Tempongko

Wannapa Suwonkerd

Affiliations

Soon will be listed here.

Abstract

Vivax malaria is a significant cause of morbidity due to malaria in northern Thailand, accounting for approximately 50% of all malaria cases. The objective of this study was to determine the behavioural factors associated with adherence to the standard 14-day course of chloroquine and primaquine, prescribed from malaria clinics, among patients with vivax malaria. A retrospective study was conducted among 206 patients living in Muang and Mae Sa Riang districts of Mae Hon Son province in northern Thailand. Data on adherence and potential behavioural factors relating to adherence were collected using a structured interviewer-administered questionnaire and supplemented with qualitative data from focus-group interviews. The results indicated that 76.21% of the 206 patients with vivax malaria did not complete the medication course. The adherence of the patients was associated with knowledge scores of malaria (adjusted odds ratio [AOR]=2.2, 95% confidence interval [CI] 1.1-4.5) and accessing drug prescription scores (AOR=5.6, 95% CI 2.13-15.3). Therefore, further effort is needed to educate patients with vivax malaria on knowledge of malaria and its treatment with simple health messages and encourage them to adhere to their treatment.

Citing Articles

A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border.

Ansari A, Aung K, Win H, Beau C, Nu B, Soe N PLOS Glob Public Health. 2025; 5(1):e0003615.

PMID: 39820011 PMC: 11737701. DOI: 10.1371/journal.pgph.0003615.

Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia.

Cassidy-Seyoum S, Chheng K, Chanpheakdey P, Meershoek A, Hsiang M, von Seidlein L PLOS Glob Public Health. 2024; 4(7):e0003476.

PMID: 39028699 PMC: 11259306. DOI: 10.1371/journal.pgph.0003476.

Long-acting intramuscular injections of ELQ-331, an antimalarial agent.

Karunakaran D, Mutyam S, Fu M, Chen J, Pham K, Pou S Eur J Pharm Sci. 2024; 198:106795.

PMID: 38729224 PMC: 11160314. DOI: 10.1016/j.ejps.2024.106795.

Kinetics of glucose-6-phosphate dehydrogenase (G6PD) activity during Plasmodium vivax infection: implications for early radical malaria treatment.

Dahuron L, Goungounga J, Drame M, Douine M, Nacher M, Blaise T Malar J. 2024; 23(1):140.

PMID: 38725027 PMC: 11080303. DOI: 10.1186/s12936-024-04973-4.

Radical cure for Plasmodium vivax malaria after G6PD qualitative testing in four provinces in Cambodia, results from Phase I implementation.

Lek D, Tsai Y, Hirano J, Sovannaroth S, Bunreth V, Vonn P Malar J. 2024; 23(1):56.

PMID: 38395925 PMC: 10893713. DOI: 10.1186/s12936-024-04884-4.

References

Mendis K, Sina B, Marchesini P, Carter R . The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001; 64(1-2 Suppl):97-106. DOI: 10.4269/ajtmh.2001.64.97. View

Orton L, Barnish G . Unit-dose packaged drugs for treating malaria. Cochrane Database Syst Rev. 2005; (2):CD004614. PMC: 6532754. DOI: 10.1002/14651858.CD004614.pub2. View

Ansah E, Gyapong J, Agyepong I, Evans D . Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. Trop Med Int Health. 2001; 6(7):496-504. DOI: 10.1046/j.1365-3156.2001.00740.x. View

Atreja A, Bellam N, Levy S . Strategies to enhance patient adherence: making it simple. MedGenMed. 2005; 7(1):4. PMC: 1681370. View

Vijaykadga S, Rojanawatsirivej C, Congpoung K, Wilairatana P, Satimai W, Uaekowitchai C . Assessment of therapeutic efficacy of chloroquine for vivax malaria in Thailand. Southeast Asian J Trop Med Public Health. 2005; 35(3):566-9. View

Somboon P, Aramrattana A, Lines J, Webber R . Entomological and epidemiological investigations of malaria transmission in relation to population movements in forest areas of north-west Thailand. Southeast Asian J Trop Med Public Health. 1998; 29(1):3-9. View

Haynes R, Yao X, Degani A, Kripalani S, Garg A, McDONALD H . Interventions to enhance medication adherence. Cochrane Database Syst Rev. 2005; (4):CD000011. DOI: 10.1002/14651858.CD000011.pub2. View

Nieto T, Mendez F, Carrasquilla G . Knowledge, beliefs and practices relevant for malaria control in an endemic urban area of the Colombian Pacific. Soc Sci Med. 1999; 49(5):601-9. DOI: 10.1016/s0277-9536(99)00134-3. View

van Benthem B, Khantikul N, Panart K, Somboon P, Oskam L . Knowledge and use of preventive measures against malaria in endemic and non-endemic villages in northern Thailand. Southeast Asian J Trop Med Public Health. 2006; 37(2):243-9. View

10.

Patel N, Crismon M, Miller A, Johnsrud M . Drug adherence: effects of decreased visit frequency on adherence to clozapine therapy. Pharmacotherapy. 2005; 25(9):1242-7. DOI: 10.1592/phco.2005.25.9.1242. View

11.

Leslie T, Abdur Rab M, Ahmadzai H, Durrani N, Fayaz M, Kolaczinski J . Compliance with 14-day primaquine therapy for radical cure of vivax malaria--a randomized placebo-controlled trial comparing unsupervised with supervised treatment. Trans R Soc Trop Med Hyg. 2004; 98(3):168-73. DOI: 10.1016/s0035-9203(03)00041-5. View

12.

Buchachart K, Krudsood S, Singhasivanon P, Treeprasertsuk S, Phophak N, Srivilairit S . Effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in Thailand. Southeast Asian J Trop Med Public Health. 2002; 32(4):720-6. View

13.

Looareesuwan S, Wilairatana P, Krudsood S, Treeprasertsuk S, Singhasivanon P, Bussaratid V . Chloroquine sensitivity of Plasmodium vivax in Thailand. Ann Trop Med Parasitol. 1999; 93(3):225-30. View

14.

Klein R, Weller S, Zeissig R, Richards F, Ruebush 2nd T . Knowledge, beliefs, and practices in relation to malaria transmission and vector control in Guatemala. Am J Trop Med Hyg. 1995; 52(5):383-8. DOI: 10.4269/ajtmh.1995.52.383. View

15.

Sattabongkot J, Tsuboi T, Zollner G, Sirichaisinthop J, Cui L . Plasmodium vivax transmission: chances for control?. Trends Parasitol. 2004; 20(4):192-8. DOI: 10.1016/j.pt.2004.02.001. View

16.

Okonkwo P, Akpala C, Okafor H, Mbah A, Nwaiwu O . Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg. 2001; 95(3):320-4. DOI: 10.1016/s0035-9203(01)90252-4. View

17.

Butraporn P, Prasittisuk C, Krachaiklin S, Chareonjai P . Behaviors in self-prevention of malaria among mobile population in east Thailand. Southeast Asian J Trop Med Public Health. 1995; 26(2):213-8. View

18.

Rosenstock I, Strecher V, BECKER M . Social learning theory and the Health Belief Model. Health Educ Q. 1988; 15(2):175-83. DOI: 10.1177/109019818801500203. View

19.

Simsek Z, Kurcer M . Malaria: knowledge and behaviour in an endemic rural area of Turkey. Public Health. 2005; 119(3):202-8. DOI: 10.1016/j.puhe.2004.03.011. View

20.

Pullar T . Compliance with drug therapy. Br J Clin Pharmacol. 1991; 32(5):535-9. PMC: 1368627. DOI: 10.1111/j.1365-2125.1991.tb03948.x. View