Meta- and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer: a HuGE-GSEC Review

Overview

Journal Am J Epidemiol

Publisher Oxford University Press

Specialty Public Health

Date 2009 Feb 26

PMID 19240225

Citations 31

Authors

Michele L Cote

Wei Chen

Daryn W Smith

Simone Benhamou

Christine Bouchardy

Dorota Butkiewicz

Kwun M Fong

Manuel Gene

Ari Hirvonen

Chikako Kiyohara

Jill E Larsen

Pinpin Lin

Ole Raaschou-Nielsen

Andrew C Povey

Edyta Reszka

Angela Risch

Joachim Schneider

Ann G Schwartz

Mette Sorensen

Jordi To-Figueras

Shinkan Tokudome

Yuepu Pu

Ping Yang

Angela S Wenzlaff

Harriet Wikman

Emanuela Taioli

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.

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