Beyond Odds Ratios--communicating Disease Risk Based on Genetic Profiles

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2009 Feb 25

PMID 19238176

Citations 75

Authors

Peter Kraft

Sholom Wacholder

Marilyn C Cornelis

Frank B Hu

Richard B Hayes

Gilles Thomas

Robert Hoover

David J Hunter

Stephen Chanock

Affiliations

Soon will be listed here.

Abstract

The brisk discovery of novel inherited disease markers by genome-wide association (GWA) studies has raised expectations for predicting disease risk by analysing multiple common alleles. However, the statistics used during the discovery phase of research (such as odds ratios or p values for association) are not the most appropriate measures for evaluating the predictive value of genetic profiles. We argue that other measures--such as sensitivity, specificity, and positive and negative predictive values--are more useful when proposing a genetic profile for risk prediction.

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