Human Telomeric DNA Sequences Have a Peroxidase Apoenzyme Activity

Overview

Journal Mol Biosyst

Publisher Royal Society of Chemistry

Specialties Biochemistry
Molecular Biology

Date 2009 Feb 20

PMID 19225613

Citations 3

Authors

Yu He

Ye Tian

Chengde Mao

Affiliations

Soon will be listed here.

Abstract

Many G-quadruplex-forming, biological DNAs, such as telomeres and a c-Myc (an oncogene) promoter region, have been shown by an in vitro study to be peroxidase apoenzymes.

Citing Articles

Molecular states and spin crossover of hemin studied by DNA origami enabled single-molecule surface-enhanced Raman scattering.

Dutta A, Tapio K, Suma A, Mostafa A, Kanehira Y, Carnevale V Nanoscale. 2022; 14(44):16467-16478.

PMID: 36305892 PMC: 9671141. DOI: 10.1039/d2nr03664a.

General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter.

Liu B, Shang H, Li D Chem Cent J. 2014; 8:43.

PMID: 25050134 PMC: 4094600. DOI: 10.1186/1752-153X-8-43.

Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications.

Yaku H, Murashima T, Miyoshi D, Sugimoto N Molecules. 2012; 17(9):10586-613.

PMID: 22951397 PMC: 6268517. DOI: 10.3390/molecules170910586.

References

Joyce G . Directed evolution of nucleic acid enzymes. Annu Rev Biochem. 2004; 73:791-836. DOI: 10.1146/annurev.biochem.73.011303.073717. View

Finkel T, Serrano M, Blasco M . The common biology of cancer and ageing. Nature. 2007; 448(7155):767-74. DOI: 10.1038/nature05985. View

von Zglinicki T, Saretzki G, Docke W, Lotze C . Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?. Exp Cell Res. 1995; 220(1):186-93. DOI: 10.1006/excr.1995.1305. View

Siddiqui-Jain A, Grand C, Bearss D, Hurley L . Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A. 2002; 99(18):11593-8. PMC: 129314. DOI: 10.1073/pnas.182256799. View

Moyzis R, Buckingham J, Cram L, Dani M, Deaven L, Jones M . A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A. 1988; 85(18):6622-6. PMC: 282029. DOI: 10.1073/pnas.85.18.6622. View

Travascio P, Li Y, Sen D . DNA-enhanced peroxidase activity of a DNA-aptamer-hemin complex. Chem Biol. 1998; 5(9):505-17. DOI: 10.1016/s1074-5521(98)90006-0. View

Collado M, Blasco M, Serrano M . Cellular senescence in cancer and aging. Cell. 2007; 130(2):223-33. DOI: 10.1016/j.cell.2007.07.003. View

Parkinson G, Lee M, Neidle S . Crystal structure of parallel quadruplexes from human telomeric DNA. Nature. 2002; 417(6891):876-80. DOI: 10.1038/nature755. View

Tian Y, He Y, Mao C . Cascade signal amplification for DNA detection. Chembiochem. 2006; 7(12):1862-4. DOI: 10.1002/cbic.200600336. View

10.

Li J, Zheng W, Kwon A, Lu Y . In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme. Nucleic Acids Res. 1999; 28(2):481-8. PMC: 102519. DOI: 10.1093/nar/28.2.481. View

11.

Li Y, Geyer C, Sen D . Recognition of anionic porphyrins by DNA aptamers. Biochemistry. 1996; 35(21):6911-22. DOI: 10.1021/bi960038h. View

12.

Amosova O, Coulter R, Fresco J . Self-catalyzed site-specific depurination of guanine residues within gene sequences. Proc Natl Acad Sci U S A. 2006; 103(12):4392-7. PMC: 1450182. DOI: 10.1073/pnas.0508499103. View

13.

Dumont P, Royer V, Pascal T, Dierick J, Chainiaux F, Frippiat C . Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett. 2001; 502(3):109-12. DOI: 10.1016/s0014-5793(01)02679-5. View

14.

Zakian V . Structure and function of telomeres. Annu Rev Genet. 1989; 23:579-604. DOI: 10.1146/annurev.ge.23.120189.003051. View

15.

Li Y, Sen D . Toward an efficient DNAzyme. Biochemistry. 1997; 36(18):5589-99. DOI: 10.1021/bi962694n. View

16.

Breaker R . Tech.Sight. Molecular biology. Making catalytic DNAs. Science. 2001; 290(5499):2095-6. DOI: 10.1126/science.290.5499.2095. View

17.

Travascio P, Bennet A, Wang D, Sen D . A ribozyme and a catalytic DNA with peroxidase activity: active sites versus cofactor-binding sites. Chem Biol. 1999; 6(11):779-87. DOI: 10.1016/s1074-5521(99)80125-2. View

18.

Blasco M . Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005; 6(8):611-22. DOI: 10.1038/nrg1656. View

19.

von Zglinicki T . Oxidative stress shortens telomeres. Trends Biochem Sci. 2002; 27(7):339-44. DOI: 10.1016/s0968-0004(02)02110-2. View

20.

Breaker R, Joyce G . A DNA enzyme that cleaves RNA. Chem Biol. 1994; 1(4):223-9. DOI: 10.1016/1074-5521(94)90014-0. View