Cellular Senescence in Cancer and Aging

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2007 Jul 31

PMID 17662938

Citations 774

Authors

Manuel Collado

Maria A Blasco

Manuel Serrano

Affiliations

Soon will be listed here.

Abstract

Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression of the INK4a/ARF locus, and DNA damage. Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.

Citing Articles

Identification of Oncogene-Induced Senescence-Associated MicroRNAs.

Foutadakis S, Soureas K, Roupakia E, Besta S, Avgeris M, Kolettas E Methods Mol Biol. 2025; 2906:189-213.

PMID: 40082357 DOI: 10.1007/978-1-0716-4426-3_11.

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.

Al Shboul S, Abu Al Karsaneh O, Alrjoub M, Al-Qudah M, El-Sadoni M, Alhesa A Int J Immunopathol Pharmacol. 2025; 39:3946320251324821.

PMID: 40070172 PMC: 11898089. DOI: 10.1177/03946320251324821.

International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.

Short E, Huckstepp R, Alavian K, Amoaku W, Barber T, van Beek E Geroscience. 2025; .

PMID: 39982667 DOI: 10.1007/s11357-025-01509-9.

Regulatory Roles of Exosomes in Aging and Aging-Related Diseases.

Xiao N, Li Q, Liang G, Qian Z, Lin Y, Zhang H Biogerontology. 2025; 26(2):61.

PMID: 39966192 DOI: 10.1007/s10522-025-10200-7.

Aging, cancer, and autophagy: connections and therapeutic perspectives.

Zapateria B, Arias E Front Mol Biosci. 2025; 11:1516789.

PMID: 39935707 PMC: 11811537. DOI: 10.3389/fmolb.2024.1516789.