Fenticonazole Activity Measured by the Methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI Against 260 Candida Vulvovaginitis Isolates from Two European Regions and Annotations on the Prevalent Genotypes

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2009 Feb 19

PMID 19223627

Citations 5

Authors

Stavroula Antonopoulou

Michel Aoun

Evangelos C Alexopoulos

Stavroula Baka

Emanuel Logothetis

Theodoros Kalambokas

Andreas Zannos

Konstantine Papadias

Odysseas Grigoriou

Evangelia Kouskouni

Aristea Velegraki

Affiliations

Soon will be listed here.

Abstract

The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient (P < 0.0001). Also, the levels of agreement for the results for itraconazole, fluconazole, and ketoconazole were 84%, 90%, and 98% (P < 0.0001), respectively. Multilocus typing by PCR fingerprinting and subsequent cluster analysis delineated geographically associated alignments for Candida albicans and fluconazole resistance-related clusters for Candida glabrata.

Citing Articles

Antifungal susceptibility testing and determination of local epidemiological cut-off values for species isolated from women with vulvovaginal candidiasis.

Kroustali V, Kanioura L, Resoulai E, Siopi M, Antonopoulou S, Meletiadis J Microbiol Spectr. 2025; 13(3):e0248824.

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Activity of Fenticonazole against and Bacterial Vaginitis Isolates Determined by Mono- or Dual-Species Testing Assays.

Sanguinetti M, Canton E, Torelli R, Tumietto F, Espinel-Ingroff A, Posteraro B Antimicrob Agents Chemother. 2019; 63(7).

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Determination of fenticonazole in human plasma by HPLC-MS/MS and its application to pharmacokinetic studies.

Mao W, Wang Y, Hu W, Jiao F, Fan H, Ding L J Pharm Anal. 2018; 7(1):63-70.

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Genotyping reveals no link between Candida albicans genotype and vaginitis severity in Turkish women.

Guzel A, Dogen A, Aydin M, Serin A, Serin M, Kalkanci A Mycopathologia. 2013; 175(3-4):287-94.

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