PI 3-kinase and Cancer: Changing Accents

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2009 Feb 3

PMID 19185485

Citations 40

Authors

Peter K Vogt

Marco Gymnopoulos

Jonathan R Hart

Affiliations

Soon will be listed here.

Abstract

Research on PI 3-kinase (PI3K) is undergoing significant shifts in emphasis. Questions that have been dormant for some time are coming to the forefront, such as the relationship of PTEN to PI3K and the role of AKT in PI3K-driven oncogenesis. Two non-alpha isoforms of Class I PI3K are now established as important determinants in cancer: p110beta and p110delta. The oncogenic activities of p110beta include a non-catalytic function, a finding that will have immediate consequences for drug development.

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