Protein Ionizable Groups: PK Values and Their Contribution to Protein Stability and Solubility

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2009 Jan 24

PMID 19164280

Citations 145

Authors

C Nick Pace

Gerald R Grimsley

J Martin Scholtz

Affiliations

Soon will be listed here.

Abstract

The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility.

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