Vitamin D Supplementation During Lactation to Support Infant and Mother
Overview
Affiliations
How human milk as the ideal infant nutrition lacks vitamin D activity leading to the severe bony deformities and muscle weakness of rickets has stymied scientists and clinicians for centuries. Recent understanding of human vitamin D requirements based on functional indicators of vitamin D activity demonstrate that the majority of humans, including lactating mothers, subsist in a vitamin D insufficient state. In this state, human milk provides inadequate vitamin D supply to the nursing infant. In contrast, with achieving maternal vitamin D sufficiency, human milk attains vitamin D activity equivalent to present infant oral supplementation. Current investigation of the role of vitamin D in diseases beyond bone health is revealing the significance of early life vitamin D sufficiency in establishing lifelong health.
Paw D, Bokiniec R, Kolodziejczyk-Nowotarska A Nutrients. 2024; 16(5).
PMID: 38474827 PMC: 10934590. DOI: 10.3390/nu16050700.
Analysis of vitamin D-sulfate and 25-hydroxyvitamin D-sulfate in breastmilk by LC-MS/MS.
Reynolds C, Dyer R, Vizenor B, Koszewski N, Singh R, Thacher T J Chromatogr B Analyt Technol Biomed Life Sci. 2023; 1232:123954.
PMID: 38101284 PMC: 10872384. DOI: 10.1016/j.jchromb.2023.123954.
Heo J, Ahn Y, Kim A, Shin S Clin Exp Pediatr. 2021; 65(9):418-429.
PMID: 34902960 PMC: 9441616. DOI: 10.3345/cep.2021.00444.
Miyagaki S, Yamaguchi M, Ota T, Kawabe Y, Morimoto H, Oka Y PLoS One. 2021; 16(3):e0247886.
PMID: 33684119 PMC: 7939371. DOI: 10.1371/journal.pone.0247886.
Oberson J, Benet S, Redeuil K, Campos-Gimenez E Anal Bioanal Chem. 2019; 412(2):365-375.
PMID: 31832707 PMC: 6992569. DOI: 10.1007/s00216-019-02248-5.