Fabrication of Modified Release Tablet Formulation of Metoprolol Succinate Using Hydroxypropyl Methylcellulose and Xanthan Gum

Overview

Journal AAPS PharmSciTech

Publisher Springer

Specialty Pharmacology

Date 2009 Jan 17

PMID 19148762

Citations 8

Authors

Mukesh C Gohel

Rajesh K Parikh

Stavan A Nagori

Dillip G Jena

Affiliations

Soon will be listed here.

Abstract

The present investigation was undertaken to fabricate modified release tablet of metoprolol succinate using hydroxypropyl methylcellulose (HPMC) and xanthan gum as a matrixing agent. A 3(2) full factorial design was employed for the optimization of formulation. The percentage drug released at a given time (Y (60), Y (240) and Y (720)) and the time required for a given percentage of drug to be released (t (50%)) were selected as dependent variables. The in vitro drug dissolution study was carried out in pH 6.8 phosphate buffer employing paddle rotated at 50 rpm. The similarity factor (f (2)) was calculated for selection of best batch considering mean in vitro dissolution data of Seloken XL as a reference profile. It is concluded that the desired drug release pattern can be obtained by using a proper combination of HPMC (high gelling ability) and xanthan gum (quick gelling tendency). The economy of xanthan gum and faster hydration rate favors its use in modified release tablets. The matrix integrity during dissolution testing was maintained by using hydroxypropyl methylcellulose.

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