MYO9B Polymorphisms in Multiple Sclerosis

Overview

Journal Eur J Hum Genet

Specialty Genetics

Date 2009 Jan 15

PMID 19142207

Citations 1

Authors

Anu Kemppinen

Minna Suvela

Pentti J Tienari

Irina Elovaara

Keijo Koivisto

Tuula Pirttila

Mauri Reunanen

Ilkka Rautakorpi

Jan Hillert

Frida Lundmark

Annette Oturai

Lars Ryder

Hanne F Harbo

Elisabeth G Celius

Aarno Palotie

Mark Daly

Leena Peltonen

Janna Saarela

Affiliations

Soon will be listed here.

Abstract

Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.

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