Selenium Status and Cardiovascular Risk Profile in Healthy Adult Saudi Males

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2009 Jan 8

PMID 19127244

Citations 5

Authors

Eman M Alissa

Waqar H Ahmed

Nabeel Al-Ama

Gordon A A Ferns

Affiliations

Soon will be listed here.

Abstract

The purpose of this research was to investigate the relationship between selenium levels, thyroid function and other coronary risk factors in 140 Saudi subjects without overt coronary heart disease stratified by age. Demographic data and serum fasting lipid profile, glucose, thyroid function tests, selenium status and dietary intake was assessed. The relationships between selenium status, thyroid function and cardiovascular risk factors were assessed by univariate and multivariate analysis. The results showed that thyroid hormone levels did not differ with age. Erythrocyte glutathione peroxidase (GPx) levels were significantly higher in the youngest vs. oldest tertile (p<0.0001). Selenium and iodine intake did not differ significantly with age tertile, but the average intake for the population sample was below the estimated average requirements for both elements. Serum lipoprotein (a) concentrations correlated with selenium (r = 0.417, p<0.0001) and TSH (r = 0.172, p<0.05). After adjustment for confounding variables; serum fT(4) and erythrocytes GPx remained significant determinants of serum TSH levels, whilst serum selenium and TSH were determinants of serum fT(4) levels. Serum Lp(a), a coronary risk factor, was strongly related to measures of selenium status. A significant relationship between measures of selenium status and thyroid function was found. Serum Lp(a) a known risk factor for cardiovascular disease was also related to selenium status in our population.

Citing Articles

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Babic Leko M, Gunjaca I, Pleic N, Zemunik T Int J Mol Sci. 2021; 22(12).

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Selenium and Health: An Update on the Situation in the Middle East and North Africa.

Ibrahim S, Kerkadi A, Agouni A Nutrients. 2019; 11(7).

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Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.

Huang J, Zhou J, Wu Y, Ren F, Lei X Free Radic Biol Med. 2018; 127:108-115.

PMID: 29800654 PMC: 6168395. DOI: 10.1016/j.freeradbiomed.2018.05.077.

A review of dietary selenium intake and selenium status in Europe and the Middle East.

Stoffaneller R, Morse N Nutrients. 2015; 7(3):1494-537.

PMID: 25734564 PMC: 4377864. DOI: 10.3390/nu7031494.

Selenium: a brief review and a case report of selenium responsive cardiomyopathy.

Al-Matary A, Hussain M, Ali J BMC Pediatr. 2013; 13:39.

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