Distinct Effects of Tafazzin Deletion in Differentiated and Undifferentiated Mitochondria

Overview

Journal Mitochondrion

Specialty Cell Biology

Date 2008 Dec 31

PMID 19114128

Citations 42

Authors

Devrim Acehan

Zaza Khuchua

Riekelt H Houtkooper

Ashim Malhotra

Johanna Kaufman

Frederic M Vaz

Mindong Ren

Howard A Rockman

David L Stokes

Michael Schlame

Affiliations

Soon will be listed here.

Abstract

Tafazzin is a conserved mitochondrial protein that is required to maintain normal content and composition of cardiolipin. We used electron tomography to investigate the effect of tafazzin deletion on mitochondrial structure and found that cellular differentiation plays a crucial role in the manifestation of abnormalities. This conclusion was reached by comparing differentiated cardiomyocytes with embryonic stem cells from mouse and by comparing different tissues from Drosophila melanogaster. The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation.

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