Sensing Voltage Across Lipid Membranes

Overview

Journal Nature

Specialty Science

Date 2008 Dec 19

PMID 19092925

Citations 173

Authors

Kenton J Swartz

Affiliations

Soon will be listed here.

Abstract

The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1-S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing.

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